Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Effects of oral contraceptives on sympathetic nerve activity during orthostatic stress in young, healthy women.
Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01590849 (Assessment of Autonomic Tone in Normotensive Women Using Combined Hormonal Oral Contraceptive Containing Drospirenone), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Autonomic Tone in Normotensive Women Using Combined Hormonal Oral Contraceptive Containing Drospirenone
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The effects of oral contraceptives on resting autonomic function and the autonomic response to physiological stressors: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- Effect of oral hormonal contraceptive pill use on the hemodynamic response to the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans.American journal of physiology. Heart and circulatory physiology · 2023Article
- Menstrual cycle effects on sympathetic neural burst amplitude distribution during orthostasis in young women.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- CORP: Standardizing methodology for assessing spontaneous baroreflex control of muscle sympathetic nerve activity in humans.American journal of physiology. Heart and circulatory physiology · 2021Article
- Measurement of compensatory reserve predicts racial differences in tolerance to simulated hemorrhage in women.The journal of trauma and acute care surgery · 2018Article
- Cardiovascular Autonomic Profile in Women With Premenstrual Syndrome.Frontiers in physiology · 2018Article
- Influence of sex, menstrual cycle, and oral contraceptives on cerebrovascular resistance and cardiorespiratory function during Valsalva or standing.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Neurovascular control of blood pressure is influenced by aging, sex, and sex hormones.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Review
- Hormone phase influences sympathetic responses to high levels of lower body negative pressure in young healthy women.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Menstrual cycle phase does not affect sympathetic neural activity in women with postural orthostatic tachycardia syndrome.The Journal of physiology · 2015Article
- Short-term administration of progesterone and estradiol independently alter carotid-vasomotor, but not carotid-cardiac, baroreflex function in young women.American journal of physiology. Heart and circulatory physiology · 2013Article
- Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol.The Journal of physiology · 2013Article
- Ovarian cycle and sympathoexcitation in premenopausal women.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Blood pressure and water regulation: understanding sex hormone effects within and between men and women.The Journal of physiology · 2012Review
- Lack of effect of ovarian cycle and oral contraceptives on baroreceptor and nonbaroreceptor control of sympathetic nerve activity in healthy women.American journal of physiology. Heart and circulatory physiology · 2012Article
- Microneurographic research in women.Frontiers in physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies report that the menstrual cycle alters sympathetic neural responses to orthostatic stress in young, eumenorrheic women. The purpose of the present study was to determine whether oral contraceptives (OC) influence sympathetic neural activation during an orthostatic challenge. Based on evidence that sympathetic baroreflex sensitivity (BRS) is increased during the "low hormone" (LH) phase (i.e., placebo pills) in women taking OC, we hypothesized an augmented muscle sympathetic nerve activity (MSNA) response to orthostatic stress during the LH phase. MSNA, mean arterial pressure (MAP), and heart rate (HR) were recorded during progressive lower body negative pressure (LBNP; -5, -10, -15, -20, -30, -40 mmHg; 3 min/stage) in 12 healthy women taking OC (age 22 +/- 1 years). Sympathetic BRS was assessed by examining relations between spontaneous fluctuations of diastolic arterial pressure and MSNA. Subjects were examined twice: once during LH phase and once approximately 3 wk after LH during the "high hormone" phase (randomized order). Resting MSNA (10 +/- 2 vs. 13 +/- 2 bursts/min), MAP (85 +/- 3 vs. 84 +/- 3 mmHg), and HR (62 +/- 2 vs. 65 +/- 3 beats/min) were not different between phases. MSNA and HR increased during progressive LBNP (P < 0.001), and these increases were similar between phases. Progressive LBNP did not change MAP during either phase. Sympathetic BRS increased during progressive LBNP, but these responses were not different between LH and high hormone phases. In conclusion, our results demonstrate that OCs do not alter cardiovascular and sympathetic neural responses to an orthostatic challenge in young, healthy women.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.