ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Cerebrovascular cyclooxygenase-1 expression, regulation, and role in hypothalamic-pituitary-adrenal axis activation by inflammatory stimuli.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Systemic inflammation and microglial activation: systematic review of animal experiments.Journal of neuroinflammation · 2015Pooled it
- Consumption of dietary emulsifiers increases sensitivity to social stress in mice: A potential role for the COX molecular pathway.Hormones and behavior · 2025Article
- Immune-neuroendocrine crosstalk in mood and psychotic disorders: A meta-analysis and systematic review.Brain, behavior, & immunity - health · 2025Review
- The role of the neuroinflammation and stressors in premenstrual syndrome/premenstrual dysphoric disorder: a review.Frontiers in endocrinology · 2025Review
- Cytomegalovirus infection of the fetal brain: intake of aspirin during pregnancy blunts neurodevelopmental pathogenesis in the offspring.Journal of neuroinflammation · 2024Article
- Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake.International journal of molecular sciences · 2023Review
- Fluorine-18 Labelled Radioligands for PET Imaging of Cyclooxygenase-2.Molecules (Basel, Switzerland) · 2022Review
- HDAC3-Regulated PGE2 Production by Microglia Induces Phobic Anxiety Susceptibility After Stroke and Pointedly Exploiting a Signal-Targeted Gamma Visual Stimulation New Therapy.Frontiers in immunology · 2022Article
- Is cyclooxygenase-1 involved in neuroinflammation?Journal of neuroscience research · 2021Review
- NSP2 Is Important for Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus to Trigger High Fever-Related COX-2-PGE2 Pathway in Pigs.Frontiers in immunology · 2021Article
- Neuroimmunology of depression.Advances in pharmacology (San Diego, Calif.) · 2021Article
- Dysregulation of HULC promotes contrast-induced nephropathy (CIN) via regulating signaling pathway of miRNA-512 and prostaglandin E1 (PGEScientific reports · 2020Article
- In vitro modeling of blood-brain barrier and interface functions in neuroimmune communication.Fluids and barriers of the CNS · 2020Review
- Lead (Pb) as a Factor Initiating and Potentiating Inflammation in Human THP-1 Macrophages.International journal of molecular sciences · 2020Article
- EP3R-Expressing Glutamatergic Preoptic Neurons Mediate Inflammatory Fever.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Stress, inflammation, and eicosanoids: an emerging perspective.Cancer metastasis reviews · 2018Review
- Prostaglandin Transporter OATP2A1/The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa.Physiological reviews · 2018Review
- Hypothalamic Microglial Activation in Obesity: A Mini-Review.Frontiers in neuroscience · 2018Review
- A Selection of Important Genes and Their Correlated Behavior in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Systemic injection of lipopolysaccharide (LPS) is a widely used model of immune/inflammatory challenge, which can invoke a host of CNS responses, including activation of the hypothalamic-pituitary-adrenal (HPA) axis. Inducible vascular prostaglandin E(2) (PGE(2)) synthesis by endothelial (ECs) and/or perivascular cells (PVCs) (a macrophage-derived vascular cell type) is implicated in the engagement of HPA and other CNS responses, by virtue of their capacity to express cyclooxygenase-2 (COX-2) and microsomal PGE(2) synthase-1. Evidence from genetic and pharmacologic studies also supports a role for the constitutively expressed COX-1 in inflammation-induced activation of the HPA axis, although histochemical evidence to support relevant localization(s) and regulation of COX-1 expression is lacking. The present experiments fill this void in showing that COX-1 immunoreactivity (IR) and mRNA are detectable in identified PVCs and parenchymal microglia under basal conditions and is robustly expressed in these and ECs 1-3 h after intravenous injection of LPS (2 microg/kg). Confocal and electron microscopic analyses indicate distinct cellular/subcellular localizations of COX-1-IR in the three cell types. Interestingly, COX-1 expression is enhanced in ECs of brain PVC-depleted rats, supporting an anti-inflammatory role of the latter cell type. Functional involvement of COX-1 is indicated by the observation that central, but not systemic, pretreatment with the selective COX-1 inhibitor SC-560 attenuated the early phase of LPS-induced increases in adrenocorticotropin and corticosterone secretion. These findings support an involvement of COX-1 in bidirectional interplay between ECs and PVCs in initiating vascular PGE(2) and downstream HPA response to proinflammatory challenges.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.