ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Positive and negative regulation of odor receptor gene choice in Drosophila by acj6.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Neurological confirmation of periplanone-D exploitation as a primary sex pheromone and counteractions of other components in the smoky brown cockroach Periplaneta fuliginosa.Cell and tissue research · 2025Article
- Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation.PLoS biology · 2025Article
- Exitron splicing of odor receptor genes inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code.Neuron · 2022Article
- Olfactory Receptor Gene Regulation in Insects: Multiple Mechanisms for Singular Expression.Frontiers in neuroscience · 2021Review
- Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system.Nature communications · 2019Article
- Thermodynamic model of gene regulation for the Or59b olfactory receptor in Drosophila.PLoS computational biology · 2019Article
- Computational genome-wide survey of odorant receptors from two solitary bees Dufourea novaeangliae (Hymenoptera: Halictidae) and Habropoda laboriosa (Hymenoptera: Apidae).Scientific reports · 2017Article
- Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates.Scientific reports · 2017Article
- Cis-regulatory mechanisms for robust olfactory sensory neuron class-restricted odorant receptor gene expression in Drosophila.PLoS genetics · 2015Article
- Chitosan/siRNA nanoparticle targeting demonstrates a requirement for single-minded during larval and pupal olfactory system development of the vector mosquito Aedes aegypti.BMC developmental biology · 2014Article
- Sensory cell fates: four defaults for the price of one.Current biology : CB · 2013Article
- Establishing and maintaining gene expression patterns: insights from sensory receptor patterning.Development (Cambridge, England) · 2013Review
- Advantage of the Highly Restricted Odorant Receptor Expression Pattern in Chemosensory Neurons of Drosophila.PloS one · 2013Article
- Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex.Genes & development · 2012Article
- Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Combinatorial activation and repression by seven transcription factors specify Drosophila odorant receptor expression.PLoS biology · 2012Article
- Chromatin modification of Notch targets in olfactory receptor neuron diversification.Nature neuroscience · 2011Article
- Sex-linked transcription factor involved in a shift of sex-pheromone preference in the silkmoth Bombyx mori.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Little is known about how individual olfactory receptor neurons (ORNs) select, from among many odor receptor genes, which genes to express. Abnormal chemosensory jump 6 (Acj6) is a POU domain transcription factor essential for the specification of ORN identity and odor receptor (Or) gene expression in the Drosophila maxillary palp, one of the two adult olfactory organs. However, the mechanism by which Acj6 functions in this process has not been investigated. Here, we systematically examine the role of Acj6 in the maxillary palp and in a major subset of antennal ORNs. We define an Acj6 binding site by a reiterative in vitro selection process. The site is found upstream of Or genes regulated by Acj6, and Acj6 binds to the site in Or promoters. Mutational analysis shows that the site is essential for Or regulation in vivo. Surprisingly, a novel ORN class in acj6 adults is found to arise from ectopic expression of a larval Or gene, which is repressed in wild type via an Acj6 binding site. Thus, Acj6 acts directly in the process of receptor gene choice; it plays a dual role, positive and negative, in the logic of the process, and acts in partitioning the larval and adult receptor repertoires.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.