ArticleMolecular biology of the cell2009
Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Hoi1 targets BLTP2 to ER-PM contact sites to regulate lipid homeostasis.The Journal of cell biology · 2026Article
- Conformational Flexibility of Transmembrane Helices: How it Works and Where it Matters.Chemical reviews · 2026Review
- Fusion Pores as Regulators of Quantal Size and Cellular Physiology.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy.Nature communications · 2025Article
- Lipid metabolism in the adrenal gland.Frontiers in endocrinology · 2025Review
- Phosphatidylserine, inflammation, and central nervous system diseases.Frontiers in aging neuroscience · 2022Review
- Function of Drosophila Synaptotagmins in membrane trafficking at synapses.Cellular and molecular life sciences : CMLS · 2021Review
- Phosphatidylserine Synthase from Salicornia europaea Is Involved in Plant Salt Tolerance by Regulating Plasma Membrane Stability.Plant & cell physiology · 2021Article
- Phosphatidylserine exposure promotes increased adhesion in Dictyostelium Copine A mutants.PloS one · 2021Article
- Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.The EMBO journal · 2020Article
- Phosphatidylserine is critical for vesicle fission during clathrin-mediated endocytosis.Journal of neurochemistry · 2020Article
- Involvement of Phosphatidylserine and Triacylglycerol in the Response of Sweet Potato Leaves to Salt Stress.Frontiers in plant science · 2019Article
- Fusion pores and their control of neurotransmitter and hormone release.The Journal of general physiology · 2017Review
- PtdInsPeLife · 2016Article
- Optogenetic monitoring identifies phosphatidylthreonine-regulated calcium homeostasis inMicrobial cell (Graz, Austria) · 2016Article
- Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.The Journal of biological chemistry · 2015Article
- Characterization of phospholipids in insulin secretory granules and mitochondria in pancreatic beta cells and their changes with glucose stimulation.The Journal of biological chemistry · 2015Article
- Analytical characterization of the role of phospholipids in platelet adhesion and secretion.Analytical chemistry · 2015Article
- Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence.PLoS biology · 2015Article
- Synaptotagmin's role in neurotransmitter release likely involves Ca(2+)-induced conformational transition.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The synaptic vesicle protein synaptotagmin I (Syt I) binds phosphatidylserine (PS) in a Ca(2+)-dependent manner. This interaction is thought to play a role in exocytosis, but its precise functions remain unclear. To determine potential roles for Syt I-PS binding, we varied the PS content in PC12 cells and liposomes and studied the effects on the kinetics of exocytosis and Syt I binding in parallel. Raising PS produced a steeply nonlinear, saturating increase in Ca(2+)-triggered fusion, and a graded slowing of the rate of fusion pore dilation. Ca(2+)-Syt I bound liposomes more tightly as PS content was raised, with a steep increase in binding at low PS, and a further gradual increase at higher PS. These two phases in the PS dependence of Ca(2+)-dependent Syt I binding to lipid may correspond to the two distinct and opposing kinetic effects of PS on exocytosis. PS influences exocytosis in two ways, enhancing an early step leading to fusion pore opening, and slowing a later step when fusion pores dilate. The possible relevance of these results to Ca(2+)-triggered Syt I binding is discussed along with other possible roles of PS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.