ArticleJournal of neurophysiology2009
Shaker and Shal mediate transient calcium-independent potassium current in a Drosophila flight motoneuron.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofbioRxiv : the preprint server for biology · 2025Article
- Modeling neurodegenerative and neurodevelopmental disorders in theLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- IntacteLife · 2022Article
- Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Transient voltage-activated KJournal of neurophysiology · 2017Article
- Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material.Neuron · 2017Article
- Apoptosis of Corneal Epithelial Cells Caused by Ultraviolet B-induced Loss of K(+) is Inhibited by Ba(2.).The ocular surface · 2016Article
- Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons.Journal of neurophysiology · 2016Article
- Article
- Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion.The Journal of physiology · 2015Article
- Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron.PLoS computational biology · 2015Article
- Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila.Frontiers in computational neuroscience · 2015Article
- Dendrites are dispensable for basic motoneuron function but essential for fine tuning of behavior.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron.The European journal of neuroscience · 2014Article
- Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron.Journal of computational neuroscience · 2013Article
- Putative excitatory and putative inhibitory inputs are localised in different dendritic domains in a Drosophila flight motoneuron.The European journal of neuroscience · 2013Article
- Temporal coherency between receptor expression, neural activity and AP-1-dependent transcription regulates Drosophila motoneuron dendrite development.Development (Cambridge, England) · 2013Article
- Preparation of Drosophila central neurons for in situ patch clamping.Journal of visualized experiments : JoVE · 2012Article
- The LIM-homeodomain protein islet dictates motor neuron electrical properties by regulating K(+) channel expression.Neuron · 2012Article
- Contribution of EAG to excitability and potassium currents in Drosophila larval motoneurons.Journal of neurophysiology · 2012Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Ionic currents underlie the firing patterns, excitability, and synaptic integration of neurons. Despite complete sequence information in multiple species, our knowledge about ion channel function in central neurons remains incomplete. This study analyzes the potassium currents of an identified Drosophila flight motoneuron, MN5, in situ. MN5 exhibits four different potassium currents, two fast-activating transient ones and two sustained ones, one of each is calcium activated. Pharmacological and genetic manipulations unravel the specific contributions of Shaker and Shal to the calcium independent transient A-type potassium currents. alpha-dendrotoxin (Shaker specific) and phrixotoxin-2 (Shal specific) block different portions of the transient calcium independent A-type potassium current. Following targeted expression of a Shaker dominant negative transgene in MN5, the remaining A-type potassium current is alpha-dendrotoxin insensitive. In Shal RNAi knock down the remaining A-type potassium current is phrixotoxin-2 insensitive. Additionally, barium blocks calcium-activated potassium currents but also a large portion of phrixotoxin-2-sensitive A-type currents. Targeted knock down of Shaker or Shal channels each cause identical reduction in total potassium current amplitude as acute application of alpha-dendrotoxin or phrixotoxin-2, respectively. This shows that the knock downs do not cause upregulation of potassium channels underlying other A-type channels during development. Immunocytochemistry and targeted expression of modified GFP-tagged Shaker channels with intact targeting sequence in MN5 indicate predominant axonal localization. These data can now be used to investigate the roles of Shaker and Shal for motoneuron intrinsic properties, synaptic integration, and spiking output during behavior by targeted genetic manipulations.
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