ArticleJournal of neurophysiology2009
Presynaptic inhibition selectively weakens peptidergic cotransmission in a small motor system.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Neural circuit regulation by identified modulatory projection neurons.Frontiers in neuroscience · 2023Review
- The dynamic range of voltage-dependent gap junction signaling is maintained byJournal of neurophysiology · 2022Article
- Perturbation-specific responses by two neural circuits generating similar activity patterns.Current biology : CB · 2021Article
- Neuropeptide Modulation Increases Dendritic Electrical Spread to Restore Neuronal Activity Disrupted by Temperature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Different microcircuit responses to comparable input from one versus both copies of an identified projection neuron.The Journal of experimental biology · 2020Article
- Similarities and differences in circuit responses to applied GlyJournal of neurophysiology · 2019Article
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- State-dependent sensorimotor gating in a rhythmic motor system.Journal of neurophysiology · 2017Article
- Circuit feedback increases activity level of a circuit input through interactions with intrinsic properties.Journal of neurophysiology · 2017Article
- Functional consequences of neuropeptide and small-molecule co-transmission.Nature reviews. Neuroscience · 2017Review
- Complicating connectomes: Electrical coupling creates parallel pathways and degenerate circuit mechanisms.Developmental neurobiology · 2017Review
- Incorporating spike-rate adaptation into a rate code in mathematical and biological neurons.Journal of neurophysiology · 2016Article
- Network feedback regulates motor output across a range of modulatory neuron activity.Journal of neurophysiology · 2016Article
- Convergent neuromodulation onto a network neuron can have divergent effects at the network level.Journal of computational neuroscience · 2016Article
- Article
- Dual-transmitter neurons: functional implications of co-release and co-transmission.Current opinion in neurobiology · 2014Review
- Convergent rhythm generation from divergent cellular mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Swim pacemaker response to bath applied neurotransmitters in the cubozoan Tripedalia cystophora.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Neuropeptide modulation of microcircuits.Current opinion in neurobiology · 2012Review
- Modulation of circuit feedback specifies motor circuit output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The presence and influence of neurons containing multiple neurotransmitters is well established, including the ability of coreleased transmitters to influence the same or different postsynaptic targets. Little is known, however, regarding whether presynaptic regulation of multitransmitter neurons influences all transmission from these neurons. Using the identified neurons and motor networks in the crab stomatogastric ganglion, we document the ability of presynaptic inhibition to selectively inhibit peptidergic cotransmission. Specifically, we determine that the gastropyloric receptor (GPR) proprioceptor neuron uses presynaptic inhibition to selectively regulate peptidergic cotransmission from the axon terminals of MCN1, a projection neuron that drives the biphasic (retraction, protraction) gastric mill (chewing) rhythm. MCN1 drives this rhythm via fast GABAergic excitation of the retraction neuron Int1 and slow peptidergic excitation of the lateral gastric (LG) protraction neuron. We first demonstrate that GPR inhibition of the MCN1 axon terminals is serotonergic and then establish that this serotonergic inhibition weakens MCN1 peptidergic excitation of LG without altering MCN1 GABAergic excitation of Int1. At the circuit level, we show that this selective regulation of MCN1 peptidergic cotransmission is necessary for the normal GPR regulation of the gastric mill rhythm. This is the first demonstration, at the level of individual identified neurons, that a presynaptic input can selectively regulate a subset of coreleased transmitters. This selective regulation changes the balance of cotransmitter actions by the target multitransmitter neuron, thereby enabling this neuron to have state-dependent actions on its target network. This finding reveals additional flexibility afforded by the ability of neurons to corelease multiple neurotransmitters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.