ArticlePlant physiology2009
Nucleotide polymorphism in the wheat transcriptional activator Spa influences its pattern of expression and has pleiotropic effects on grain protein composition, dough viscoelasticity, and grain hardness.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 72 citations in OpenAlex.
- Validated reference genes for normalization of RT-qPCR in developing organs of wheat to study developmentally/spatio-temporally expressed family genes.Scientific reports · 2025Article
- Storage protein activator controls grain protein accumulation in bread wheat in a nitrogen dependent manner.Scientific reports · 2023Article
- Transcriptome Analysis Reveals Potential Mechanism in Storage Protein Trafficking within Developing Grains of Common Wheat.International journal of molecular sciences · 2022Article
- Promoter DNA hypermethylation ofJournal of advanced research · 2022Article
- Wheat Quality Formation and Its Regulatory Mechanism.Frontiers in plant science · 2022Review
- A novel NAC family transcription factor SPR suppresses seed storage protein synthesis in wheat.Plant biotechnology journal · 2021Article
- Biochemical and Genetic Approaches Improving Nitrogen Use Efficiency in Cereal Crops: A Review.Frontiers in plant science · 2021Review
- High-Molecular-Weight Glutenin Subunits: Genetics, Structures, and Relation to End Use Qualities.International journal of molecular sciences · 2020Review
- Omics Data Reveal Putative Regulators of Einkorn Grain Protein Composition under Sulfur Deficiency.Plant physiology · 2020Article
- Adaptive strategy of allohexaploid wheat to long-term salinity stress.BMC plant biology · 2020Article
- Over-ExpressingInternational journal of molecular sciences · 2020Article
- Genomic and functional genomics analyses of gluten proteins and prospect for simultaneous improvement of end-use and health-related traits in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Allele mining of TaGRF-2D gene 5'-UTR in Triticum aestivum and Aegilops tauschii genotypes.PloS one · 2020Article
- Genetic dissection of a major QTL for kernel weight spanning the Rht-B1 locus in bread wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- An extracted tetraploid wheat harbouring the BBAA component of common wheat shows anomalous shikimate and sucrose metabolism.BMC plant biology · 2019Article
- A newly formed hexaploid wheat exhibits immediate higher tolerance to nitrogen-deficiency than its parental lines.BMC plant biology · 2018Article
- An OverexpressedG3 (Bethesda, Md.) · 2018Article
- A Catalog of Regulatory Sequences for Trait Gene for the Genome Editing of Wheat.Frontiers in plant science · 2016Article
- Genome-wide association study of phosphorus-deficiency-tolerance traits in Aegilops tauschii.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Molecular characterization and expression profiling of the protein disulfide isomerase gene family in Brachypodium distachyon L.PloS one · 2014Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Storage protein activator (SPA) is a key regulator of the transcription of wheat (Triticum aestivum) grain storage protein genes and belongs to the Opaque2 transcription factor subfamily. We analyzed the sequence polymorphism of the three homoeologous Spa genes in hexaploid wheat. The level of polymorphism in these genes was high particularly in the promoter. The deduced protein sequences of each homoeolog and haplotype show greater than 93% identity. Two major haplotypes were studied for each Spa gene. The three Spa homoeologs have similar patterns of expression during grain development, with a peak in expression around 300 degree days after anthesis. On average, Spa-B is 10 and seven times more strongly expressed than Spa-A and Spa-D, respectively. The haplotypes are associated with significant quantitative differences in Spa expression, especially for Spa-A and Spa-D. Significant differences were found in the quantity of total grain nitrogen allocated to the gliadin protein fractions for the Spa-A haplotypes, whereas the synthesis of glutenins is not modified. Genetic association analysis between Spa and dough viscoelasticity revealed that Spa polymorphisms are associated with dough tenacity, extensibility, and strength. Except for Spa-A, these associations can be explained by differences in grain hardness. No association was found between Spa markers and the average single grain dry mass or grain protein concentration. These results demonstrate that in planta Spa is involved in the regulation of grain storage protein synthesis. The associations between Spa and dough viscoelasticity and grain hardness strongly suggest that Spa has complex pleiotropic functions during grain development.
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