ArticleJournal of virology2010
The poxvirus A35 protein is an immunoregulator.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Effect of the C12L, A35R, A40R, and A41L Genes of MVA Vector on the Immunogenicity of Recombinant MVA Expressing the SARS-CoV-2 Spike Protein.Bulletin of experimental biology and medicine · 2025Article
- Mpox virus: virology, molecular epidemiology, and global public health challenges.Frontiers in microbiology · 2025Review
- Article
- Enhancing the Immunogenicity of Vaccinia Virus.Viruses · 2022Article
- Gene amplification acts as a molecular foothold to facilitate cross-species adaptation and evasion of multiple antiviral pathways.Virus evolution · 2022Article
- Review
- Article
- The effects of diets enriched in omega-3 polyunsaturated fatty acids on systemic vaccinia virus infection.Scientific reports · 2017Article
- Antigen presentation assays to investigate uncharacterized immunoregulatory genes.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Attenuation of vaccinia Tian Tan strain by removal of viral TC7L-TK2L and TA35R genes.PloS one · 2012Article
- Deletion of the A35 gene from Modified Vaccinia Virus Ankara increases immunogenicity and isotype switching.Vaccine · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
It was shown previously that the highly conserved vaccinia virus A35 gene is an important virulence factor in respiratory infection of mice. We show here that A35 is also required for full virulence by the intraperitoneal route of infection. A virus mutant in which the A35 gene has been removed replicated normally and elicited improved antibody, gamma interferon-secreting cell, and cytotoxic T-lymphocyte responses compared to wild-type virus, suggesting that A35 increases poxvirus virulence by immunomodulation. The enhanced immune response correlated with an improved control of viral titers in target organs after the development of the specific immune response. Finally, the A35 deletion mutant virus also provided protection from lethal challenge (1,000 50% lethal doses) equal to that of the wild-type virus. Together, these data suggest that A35 deletion viruses will make safer and more efficacious vaccines for poxviruses. In addition, the A35 deletion viruses will serve as improved platform vectors for other infectious diseases and cancer and will be superior vaccine choices for postexposure poxvirus vaccination, as they also provide improved kinetics of the immune response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.