ArticleJournal of the Royal Society, Interface2010
Estimating Young's modulus of zona pellucida by micropipette aspiration in combination with theoretical models of ovum.
Article in Journal of the Royal Society, Interface, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 100 citations in OpenAlex.
- Metaphase I-arrest oocyte with agar-like zona pellucida, abandon or not abandon?Journal of ovarian research · 2026Article
- TheMaterials today. Bio · 2026Review
- Non-invasive biomechanical characterization of embryos using microfluidic cantilevers.European biophysics journal : EBJ · 2026Article
- The human Zona-Pellucida shear modulus before and after fertilization and its implications in IVF embryo selection.Scientific reports · 2026Article
- Biophysical, cellular, and mouse model approaches to investigate the mechanical regulation of folliculogenesis.Seminars in cell & developmental biology · 2025Review
- Hyperelastic models for the human zona pellucida and their implications on shear modulus estimation in the clinical practice.Scientific reports · 2024Article
- The Synergic Effect of Tubal Endometriosis and Women's Aging on Fallopian Tube Function: Insights from a 3D Mechanical Model.Bioengineering (Basel, Switzerland) · 2024Article
- Micro/Nanorobotics in In Vitro Fertilization: A Paradigm Shift in Assisted Reproductive Technologies.Micromachines · 2024Review
- Development and evaluation of a usable blastocyst predictive model using the biomechanical properties of human oocytes.PloS one · 2024Article
- How great thou ART: biomechanical properties of oocytes and embryos as indicators of quality in assisted reproductive technologies.Frontiers in cell and developmental biology · 2024Review
- Viscoelastic Properties of Zona Pellucida of Oocytes Characterized by Transient Electrical Impedance Spectroscopy.Biosensors · 2023Article
- Mechanical Characterization and Modelling of Subcellular Components of Oocytes.Micromachines · 2022Article
- Dynamic shapes of the zygote and two-cell mouse and human.Biology open · 2021Article
- Scanning Probe Microscopies: Imaging and Biomechanics in Reproductive Medicine Research.International journal of molecular sciences · 2021Review
- Visco- and poroelastic contributions of the zona pellucida to the mechanical response of oocytes.Biomechanics and modeling in mechanobiology · 2021Article
- Zona pellucida shear modulus, a possible novel non-invasive method to assist in embryo selection during in-vitro fertilization treatment.Scientific reports · 2020Article
- The quagga mussel genome and the evolution of freshwater tolerance.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Study of the mechanical properties of fresh and cryopreserved individual human oocytes.European biophysics journal : EBJ · 2019Article
- Robotic Micropipette Aspiration for Multiple Cells.Micromachines · 2019Article
- Advances in Micropipette Aspiration: Applications in Cell Biomechanics, Models, and Extended Studies.Biophysical journal · 2019Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zona pellucida (ZP) is the spherical layer that surrounds the mammalian oocyte. The physical hardness of this layer plays a crucial role in fertilization and is largely unknown because of the lack of appropriate measuring and modelling methods. The aim of this study is to measure the biomechanical properties of the ZP of human/mouse ovum and to test the hypothesis that Young's modulus of the ZP varies with fertilization. Young's moduli of ZP are determined before and after fertilization by using the micropipette aspiration technique, coupled with theoretical models of the oocyte as an elastic incompressible half-space (half-space model), an elastic compressible bilayer (layered model) or an elastic compressible shell (shell model). Comparison of the models shows that incorporation of the layered geometry of the ovum and the compressibility of the ZP in the layered and shell models may provide a means of more accurately characterizing ZP elasticity. Evaluation of results shows that although the results of the models are different, all confirm that the hardening of ZP will increase following fertilization. As can be seen, different choices of models and experimental parameters can affect the interpretation of experimental data and lead to differing mechanical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.