ArticleThe Journal of biological chemistry2009
Regulation of iron homeostasis in Arabidopsis thaliana by the clock regulator time for coffee.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- Magnesium: An overlooked signalling ion in plant physiology and circadian regulation.Quantitative plant biology · 2026Review
- What Is Similar, What Is Different? Characterization of Mitoferrin-like Proteins fromInternational journal of molecular sciences · 2025Article
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Shedding light on iron nutrition: exploring intersections of transcription factor cascades in light and iron deficiency signaling.Journal of experimental botany · 2025Review
- Variations in Circadian Clock Organization & Function: A Journey from Ancient to Recent.Planta · 2022Review
- Molecular signatures of parallel adaptive divergence causing reproductive isolation and speciation across two genera.Innovation (Cambridge (Mass.)) · 2022Article
- The circadian clock ticks in plant stress responses.Stress biology · 2022Review
- Article
- Impact of the SnRK1 protein kinase on sucrose homeostasis and the transcriptome during the diel cycle.Plant physiology · 2021Article
- A Novel Signaling Pathway Required for Arabidopsis Endodermal Root Organization Shapes the Rhizosphere Microbiome.Plant & cell physiology · 2021Article
- Iron metabolism strategies in diatoms.Journal of experimental botany · 2021Review
- Network Topological Analysis for the Identification of Novel Hubs in Plant Nutrition.Frontiers in plant science · 2021Article
- Regulation of Iron Homeostasis and Use in Chloroplasts.International journal of molecular sciences · 2020Review
- The Geomagnetic Field Is a Contributing Factor for an Efficient Iron Uptake inFrontiers in plant science · 2020Article
- Changes in the Elemental and Metabolite Profile of Wheat Phloem Sap during Grain Filling Indicate a Dynamic between Plant Maturity and Time of Day.Metabolites · 2018Article
- Beyond Histones: New Substrate Proteins of Lysine Deacetylases in Arabidopsis Nuclei.Frontiers in plant science · 2018Article
- The plant leaf movement analyzer (PALMA): a simple tool for the analysis of periodic cotyledon and leaf movement inPlant methods · 2017Article
- The Plant Circadian Clock: From a Simple Timekeeper to a Complex Developmental Manager.Cold Spring Harbor perspectives in biology · 2016Review
- Identification of Evening Complex Associated Proteins in Arabidopsis by Affinity Purification and Mass Spectrometry.Molecular & cellular proteomics : MCP · 2016Article
- Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plants, iron homeostasis is tightly regulated to supply sufficient amounts of this metal for an optimal growth while preventing excess accumulation to avoid oxidative stress. To identify new regulators of iron homeostasis, a luciferase-based genetic screen using the Arabidopsis AtFer1 ferritin promoter as a target was developed. This screen identified TIME FOR COFFEE (TIC) as a regulator of AtFer1 gene expression. TIC was previously described as a nuclear regulator of the circadian clock. Mutants in the TIC gene exhibited a chlorotic phenotype rescued by exogenous iron addition and are hypersensitive to iron during the early stages of development. We showed that iron overload-responsive genes are regulated by TIC and by the central oscillator of the circadian clock. TIC represses their expression under low iron conditions, and its activity requires light and light/dark cycles. Regarding AtFer1, this repression is independent of the previously characterized cis-acting element iron-dependent regulatory sequence, known to be involved in AtFer1 repression. These results showed that the regulation of iron homeostasis in plants is a major output of the TIC- and central oscillator-dependent signaling pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.