ReviewCurrent opinion in neurobiology2009
New photochemical tools for controlling neuronal activity.
Review in Current opinion in neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 157 citations in OpenAlex.
- Thermophoresis induced by photothermal shock alters reversal potential and capacitance in neurons.Biophysical journal · 2026Article
- Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Nanoparticle-based optical interfaces for retinal neuromodulation: a review.Frontiers in cellular neuroscience · 2024Review
- Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision.Journal of translational medicine · 2022Review
- Response of a neuronal network computational model to infrared neural stimulation.Frontiers in computational neuroscience · 2022Article
- Current perspective on retinal remodeling: Implications for therapeutics.Frontiers in neuroanatomy · 2022Article
- Current Review of Optical Neural Interfaces for Clinical Applications.Micromachines · 2021Review
- Light: A Magical Tool for Controlled Drug Delivery.Advanced functional materials · 2020Article
- Advances in adaptive optics-based two-photon fluorescence microscopy for brain imaging.Lasers in medical science · 2020Review
- Caged Proline in Photoinitiated Organocatalysis.The Journal of organic chemistry · 2019Article
- A compact holographic projector module for high-resolution 3D multi-site two-photon photostimulation.PloS one · 2019Article
- Novel Riboflavin-Inspired Conjugated Bio-Organic Semiconductors.Molecules (Basel, Switzerland) · 2018Article
- New techniques, applications and perspectives in neuropeptide research.The Journal of experimental biology · 2018Review
- Genetic Code Expansion and Optoproteomics.The Yale journal of biology and medicine · 2017Review
- Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke.Progress in neurobiology · 2017Review
- Flash-and-Freeze: A Novel Technique to Capture Membrane Dynamics with Electron Microscopy.Journal of visualized experiments : JoVE · 2017Article
- TRPA1 expression and its functional activation in rodent cortex.Open biology · 2017Article
- A photocaged, cyclopropene-containing analog of the amino acid neurotransmitter glutamate.Tetrahedron letters · 2016Article
- Article
- Advances in Gene Therapy for Diseases of the Eye.Human gene therapy · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Neurobiology has entered a new era in which optical methods are challenging electrophysiological techniques for their value in measuring and manipulating neuronal activity. This change is occurring largely because of the development of new photochemical tools, some synthesized by chemists and some provided by nature. This review is focused on the three types of photochemical tools for neuronal control that have emerged in recent years. Caged neurotransmitters, including caged glutamate, are synthetic molecules that enable highly localized activation of neurotransmitter receptors in response to light. Natural photosensitive proteins, including channelrhodopsin-2 and halorhodopsin, can be exogenously expressed in neurons and enable rapid photocontrol of action potential firing. Synthetic small molecule photoswitches can bestow light-sensitivity on native or exogenously expressed proteins, including K(+) channels and glutamate receptors, allowing photocontrol of action potential firing and synaptic events. At a rapid pace, these tools are being improved and new tools are being introduced, thanks to molecular biology and synthetic chemistry. The three families of photochemical tools have different capabilities and uses, but they all share in enabling precise and noninvasive exploration of neural function with light.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.