Trial reportPsychoneuroendocrinology2010
CRH-stimulated cortisol release and food intake in healthy, non-obese adults.
Trial report in Psychoneuroendocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 142 citations in OpenAlex.
- Association of admission cortisol levels with outcomes and treatment response in patients at nutritional risk : A secondary analysis of a randomized clinical trial.Nutrition journal · 2023Trial
- Trial
- Characterization of the corticotropin-releasing hormone family in largemouth bass and their expression profiles in response to feeding and acute and chronic heat stress.Journal of fish biology · 2026Article
- Neuropsychological and metabolic interconnectivity in obesity, anorexia and bulimia nervosa - an integrative literature review.Metabolic brain disease · 2026Review
- Effects of aerobic exercise and computer-based cognitive training on cognition, functional independence, quality of life, and salivary cortisol levels in older adults with mild cognitive impairment: a randomized trial.Frontiers in aging neuroscience · 2026Article
- From shared mechanisms to treatment gaps: a review of the comorbidity between eating disorders and PTSD.Journal of eating disorders · 2025Review
- Impact of Dietary Enrichment with Omega-3 Polyunsaturated Fatty Acids from Extruded Linseed andAnimals : an open access journal from MDPI · 2025Article
- Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes.Diabetes · 2025Article
- A review of the literature on wellbeing and modifiable dementia risk factors.Ageing research reviews · 2024Review
- POMC-specific knockdown of MeCP2 leads to adverse phenotypes in mice chronically exposed to high fat diet.Behavioural brain research · 2024Article
- Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells.Scientific reports · 2024Article
- NPFF Decreases Activity of Human Arcuate NPY Neurons: A Study in Embryonic-Stem-Cell-Derived Model.International journal of molecular sciences · 2022Article
- Stress-induced alterations in HPA-axis reactivity and mesolimbic reward activation in individuals with emotional eating.Appetite · 2022Article
- Mapping the network biology of metabolic response to stress in posttraumatic stress disorder and obesity.Frontiers in psychology · 2022Article
- Perceived stress and eating behavior among residents in a teaching hospital.Journal of family medicine and primary care · 2021Article
- Article
- Effects of Growth Hormone Receptor Ablation in Corticotropin-Releasing Hormone Cells.International journal of molecular sciences · 2021Article
- Cortisol in relation to problematic eating behaviours, adiposity and symptom profiles in Major Depressive Disorder.Comprehensive psychoneuroendocrinology · 2021Article
- Article
- Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring.The Journal of nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is considerable anecdotal and some scientific evidence that stress triggers eating behavior, but underlying physiological mechanisms remain uncertain. The hypothalamic-pituitary-adrenal (HPA) axis is a key mediator of physiological stress responses and may play a role in the link between stress and food intake. Cortisol responses to laboratory stressors predict consumption but it is unclear whether such responses mark a vulnerability to stress-related eating or whether cortisol directly stimulates eating in humans.
methodsWe infused healthy adults with corticotropin-releasing hormone (CRH) at a dose that is subjectively undetectable but elicits a robust endogenous cortisol response, and measured subsequent intake of snack foods, allowing analysis of HPA reactivity effects on food intake without the complex psychological effects of a stress paradigm.
resultsCRH elevated cortisol levels relative to placebo but did not impact subjective anxious distress. Subjects ate more following CRH than following placebo and peak cortisol response to CRH was strongly related to both caloric intake and total consumption.
conclusionsThese data show that HPA axis reactivity to pharmacological stimulation predicts subsequent food intake and suggest that cortisol itself may directly stimulate food consumption in humans. Understanding the physiological mechanisms that underlie stress-related eating may prove useful in efforts to attack the public health crises created by obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.