ArticlePediatric exercise science2009
Circulating T-regulatory cells, exercise and the elite adolescent swimmer.
Article in Pediatric exercise science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial.Journal of the International Society of Sports Nutrition · 2021Trial
- The immune system in sporadic inclusion body myositis patients is not compromised by blood-flow restricted exercise training.Arthritis research & therapy · 2019Trial
- Evaluating a Multiscale Mechanistic Model of the Immune System to Predict Human Immunogenicity for a Biotherapeutic in Phase 1.The AAPS journal · 2019Trial
- An attempt to induce an immunomodulatory effect in rowers with spirulina extract.Journal of the International Society of Sports Nutrition · 2018Trial
- Metabolic, Mental and Immunological Effects of Normoxic and Hypoxic Training in Multiple Sclerosis Patients: A Pilot Study.Frontiers in immunology · 2018Trial
- Regulatory mechanisms of high-polyphenol dietary intervention on exercise-induced immunosuppression during high-intensity training periods in adolescent athletes: a systems biology analysis based on immune-metabolic pathways.Nutrition & metabolism · 2026Article
- Exercise workload: a key determinant of immune health - a narrative review.Frontiers in immunology · 2025Review
- Environment, Lifestyles, and Climate Change: The Many Nongenetic Contributors to The Long and Winding Road to Autoimmune Diseases.Arthritis care & research · 2025Review
- The Effect of Aerobic Exercise and Low-Impact Pilates Workout on the Adaptive Immune System.Journal of clinical medicine · 2022Article
- Recommendations for Resuming PA after Prolonged Rest in Children and Adolescents: A Systematic Integrative Review of Relevance for Immunity.Journal of functional morphology and kinesiology · 2022Review
- Regular Exercise May Restore Certain Age-Related Alterations of Adaptive Immunity and Rebalance Immune Regulation.Frontiers in immunology · 2021Article
- The Effect of Physical Training on Peripheral Blood Mononuclear Cell Ex Vivo Proliferation, Differentiation, Activity, and Reactive Oxygen Species Production in Racehorses.Antioxidants (Basel, Switzerland) · 2020Article
- Exercise increases skin graft resistance to rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood.Aging cell · 2018Article
- T-regulatory cells exhibit a biphasic response to prolonged endurance exercise in humans.European journal of applied physiology · 2017Article
- Exercise-Induced Release of Pharmacologically Active Substances and Their Relevance for Therapy of Hepatic Injury.Frontiers in pharmacology · 2016Review
- Rapid Exercise-Induced Mobilization of Dendritic Cells Is Potentially Mediated by a Flt3L- and MMP-9-Dependent Process in Multiple Sclerosis.Mediators of inflammation · 2015Article
- The influence of exercise training status on antigen-stimulated IL-10 production in whole blood culture and numbers of circulating regulatory T cells.European journal of applied physiology · 2013Article
- The effect of pre-competition training on biochemical indices and immune function of volleyball players.International journal of clinical and experimental medicine · 2013Article
- The Pro- and Anti-Inflammatory Cytokine Response to Exercise in Adolescent Swimmers.Pediatric asthma, allergy & immunology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Brief high intensity exercise induces peripheral leukocytosis possibly leading to a higher incidence of allergic symptoms in athletes undergoing excessive training. We studied the exercise-induced alternation of circulating Tregs and FoxP3+ Tregs due to acute intense swim exercise in elite swimmers (n = 22, 12 males, age = 15.4 yrs). Twelve had prior or current rhinitis or asthma and 10 had no current or prior allergy or asthma. Circulating Tregs increased significantly (p < .001) following exercise (pre = 133 +/- 11.2, post = 196 +/- 17.6) as did FoxP3+ cells (pre = 44, post = 64 cells/microl). Increases in Tregs and FoxP3+ Tregs occurred to the same extent in both groups of adolescent swimmers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.