ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2010
Experimental autoimmune encephalomyelitis in the common marmoset, a bridge between rodent EAE and multiple sclerosis for immunotherapy development.
Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Validation of a human-specific, multiplex platform for detecting common marmoset (Callithrix jacchus) inflammatory analytes.Cellular immunology · 2026Article
- Animal models of multiple sclerosis: applications and future directions in disease research.Metabolic brain disease · 2026Review
- In vivo MRI is sensitive to remyelination in a nonhuman primate model of multiple sclerosis.eLife · 2023Article
- Delimiting MOGAD as a disease entity using translational imaging.Frontiers in neurology · 2023Review
- Review
- Anti-CD20 treatment effectively attenuates cortical pathology in a rat model of widespread cortical demyelination.Journal of neuroinflammation · 2021Article
- The spectrum of spinal cord lesions in a primate model of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Potential role of iron in repair of inflammatory demyelinating lesions.The Journal of clinical investigation · 2019Article
- Spatiotemporal distribution of fibrinogen in marmoset and human inflammatory demyelination.Brain : a journal of neurology · 2018Article
- Viruses in chronic progressive neurologic disease.Multiple sclerosis (Houndmills, Basingstoke, England) · 2018Review
- Common marmoset (Callithrix jacchus) as a primate model for behavioral neuroscience studies.Journal of neuroscience methods · 2017Article
- A New Targeted Model of Experimental Autoimmune Encephalomyelitis in the Common Marmoset.Brain pathology (Zurich, Switzerland) · 2016Article
- Custom fit 3D-printed brain holders for comparison of histology with MRI in marmosets.Journal of neuroscience methods · 2016Article
- Increased Meningeal T and Plasma Cell Infiltration is Associated with Early Subpial Cortical Demyelination in Common Marmosets with Experimental Autoimmune Encephalomyelitis.Brain pathology (Zurich, Switzerland) · 2015Article
- Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain.Annals of clinical and translational neurology · 2014Article
- Overview of models, methods, and reagents developed for translational autoimmunity research in the common marmoset (Callithrix jacchus).Experimental animals · 2013Review
- In vivo quantification of T₂ anisotropy in white matter fibers in marmoset monkeys.NeuroImage · 2012Article
- LPS-induced lung inflammation in marmoset monkeys - an acute model for anti-inflammatory drug testing.PloS one · 2012Article
- Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS).British journal of pharmacology · 2011Review
- Effects of early IL-17A neutralization on disease induction in a primate model of experimental autoimmune encephalomyelitis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The attrition rate of new drugs for central nervous system diseases including multiple sclerosis (MS) is very high. A widely recognized bottleneck in the selection of promising central nervous system drug candidates from the development pipeline is the lack of sufficiently predictive animal models. Here, we review how the experimental autoimmune encephalomyelitis (EAE) model in the Neotropical primate "common marmoset" can help to bridge the gap between rodent EAE models and MS. The EAE model in the marmoset closely resembles MS in the clinical as well as pathological presentation and can be used for fundamental research into immunopathogenic mechanisms and for therapy development. We discuss recent insights arising from this model, both on novel therapeutics and immunopathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.