ArticleDigestive diseases and sciences2010
Diagnostic role and clinical association of ASCA and ANCA in Brazilian patients with inflammatory bowel disease.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- New Insights on CD8Frontiers in immunology · 2021Review
- Can molecular stratification improve the treatment of inflammatory bowel disease?Pharmacological research · 2019Review
- Variable outcome in infantile-onset inflammatory bowel disease in an Asian cohort.World journal of gastroenterology · 2016Observational
- Hidden musculoskeletal involvement in inflammatory bowel disease: a multicenter ultrasound study.BMC musculoskeletal disorders · 2016Article
- Antineutrophil cytoplasmic antibodies in patients treated with methimazole: a prospective Brazilian study.Brazilian journal of otorhinolaryngologyArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-Saccharomyces cerevisae antibody (ASCA) and perinuclear anti-neutrophil cytoplasmatic antibody (pANCA) remain the most well-established markers in inflammatory bowel disease (IBD), and both may be associated with disease phenotype.
aimTo determine the utility of ASCA and pANCA as markers in a Brazilian cohort of IBD patients. MATERIALS AND
methodsA total of 90 patients with ulcerative colitis (UC), 77 patients with Crohn's disease (CD), and 57 healthy individuals were included in the study. ASCA was determined by enzyme-linked immunosorbent assay (ELISA) and pANCA by immunofluorescence assay.
resultsIn support of diagnosis of UC, the sensitivity and specificity of pANCA were 51% and 100%, respectively. ASCA (IgA or IgG isotypes) presented sensitivity of 62% and specificity of 93% for CD. The combination of ASCA negativity and pANCA positivity (ASCA-/pANCA+) displayed sensitivity of 43% and specificity of 100% for diagnosis to UC. In CD patients, ASCA+/pANCA- presented sensitivity and specificity of 57% and 93%, respectively. Additionally, ASCA positivity correlated with early age at disease onset and ileal location in CD patients. In UC patients, pANCA positivity was correlated with pancolitis or left colitis.
conclusionsThe results evidenced that low sensitivity of ASCA and pANCA markers limits their use in IBD screening in the general population; however, their specificity may contribute to differentiation between CD and UC in IBD patients. Our study lends further support to the suggestion that serologic assessment identifies different subtypes of IBD.
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