ArticleMolecular biology reports2010
SDF1-3' G801A polymorphisms in Polish patients with systemic lupus erythematosus.
Article in Molecular biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Relationship between rs1801157 polymorphism in stromal cell-derived factor gene and systemic lupus erythematosus risk.Oncotarget · 2017Article
- Article
- Genetics of Lupus Nephritis: Clinical Implications.Seminars in nephrology · 2015Review
- Contribution of toll-like receptor 9 gene single-nucleotide polymorphism to systemic lupus erythematosus.Rheumatology international · 2013Article
- The SDF-1α3'A genetic variation is correlated with susceptibility of asthma in Iranian patients.BioMed research international · 2013Article
- A novel autologous cell-based therapy to promote diabetic wound healing.Annals of surgery · 2012Article
- Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population.Molecular biology reports · 2012Article
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Authors and funding
4 authors.
Funding
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Abstract
It has been reported that stromal cell-derived factor-1 (SDF1), currently also designated CXCL12, plays a significant role in the development of nephritis and death in the lupus mice model. Using restriction length fragment polymorphism (RFLP) analysis we assessed the frequencies of SDF1-3' G801A (rs 1801157) polymorphic variants between systemic lupus erythematosus (SLE) patients (n = 150) and controls (n = 300). There were no significant differences in the prevalence of SDF1-3' G801A polymorphic variants in SLE patients and healthy individuals. However, we observed that the SDF1-3' A/A and G/A genotypes (recessive model) contributed to renal manifestations of SLE OR = 3.042 (95% CI = 1.527-6.058, P = 0.002), and the p value stayed statistically significant after Bonferroni correction (p(corr) = 0.032) in SLE patients. We also found an association of the SDF1-3' A/A and G/A genotypes (recessive model) with dermal manifestations of SLE OR = 2.510 (95% CI = 1.247-5.052, P = 0.0122), (p(corr) = 0.1952) but this did not remain statistically significant after Bonferroni correction. Our observations suggest that the SDF1-3' G801A genotype may be associated with some clinical manifestations in patients with SLE.
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