Evidence map›Paper›PMID 19826838›Full record

ArticleJournal of cancer research and clinical oncology2010

Urokinase expression in course of benign and malignant mammary lesions: comparison between nodular and healthy tissues.

Francesca Ceccarelli, Andrea Fuso, Liana Civitelli, Ersilia Ranieri, Giuliana Caprio, Paola Pagni, Mario Rengo, Sigfrido Scarpa

Registry-linked trialOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01663792 (Dietary Seaweed and Early Breast Cancer), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01663792 nacompletednot on this map

Dietary Seaweed and Early Breast Cancer: A Randomized Trial

TypeinterventionalSponsorUniversity of South CarolinaRan2006 to 2007Enrolled15ConditionsSeaweed Associated Changes in Healthy SubjectsArmsSeaweed, Placebo, Placebo2
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Francesca CeccarelliUOC Medicina territoriale chirurgica e prevenzione oncologica, Department of Surgery "P. Valdoni", Sapienza University of Rome, C.so Vittorio Emanuele II, 244, 00186 Rome, Italy.
Andrea Fuso
Liana Civitelli
Ersilia Ranieri
Giuliana Caprio
Paola Pagni
Mario Rengo
Sigfrido Scarpa
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIncreased expression of urokinase (uPA), a member of the serine protease family, is an effector of metastatic cascade and has been reported in various malignancies, including breast cancer. uPA overexpression in cancer tissues was correlated with a more aggressive phenotype and it is considered a strong and independent unfavorable prognostic factor in breast cancer.

methodsUsing real-time PCR assay, we analyzed uPA expression of malignant and benign breast nodular lesions versus healthy tissues (normal breast and lymphocytes).

resultsWe found that besides breast cancer nodule, normal mammary gland and lymphocytes overexpressed uPA too. Tissues obtained from women with benign lesions expressed homogeneous and lower uPA.

conclusionsIn conclusion, although uPA overexpression is typical of cancer tissues, it could be considered as a feature of the whole organism affected by cancer. On the basis of these first results, uPA could be considered for further studies as a possible useful therapeutic target in breast cancer.

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticAdultAgedAged, 80 and overBreastBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleHumansLymphocytesMiddle AgedReverse Transcriptase Polymerase Chain ReactionUrokinase-Type Plasminogen ActivatorErb-b2 Receptor Tyrosine KinasesUrokinase-Type Plasminogen Activator

Identifiers

PMID19826838
PMCPMC11828343
OpenAlexW1963810816

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.