ArticleEuropean journal of human genetics : EJHG2010
Comparison of participant information and informed consent forms of five European studies in genetic isolated populations.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Protein profiling reveals consequences of lifestyle choices on predicted biological aging.Scientific reports · 2015Trial
- Identification of genetic variants influencing the human plasma proteome.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Challenges Faced by Behavioral Genetic Studies: Researchers Perspective from the MENA Region.Current genomics · 2021Article
- Article
- Improved power and precision with whole genome sequencing data in genome-wide association studies of inflammatory biomarkers.Scientific reports · 2019Article
- Informed Consent in the Newly Established Biobank.International journal of environmental research and public health · 2019Article
- The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases.PLoS genetics · 2017Article
- Tea and coffee consumption in relation to DNA methylation in four European cohorts.Human molecular genetics · 2017Article
- Social and Communicative Functions of Informed Consent Forms in East Asia and Beyond.Frontiers in genetics · 2017Article
- Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15.Human molecular genetics · 2016Article
- Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs.Nature communications · 2014Article
- Practical barriers and ethical challenges in genetic data sharing.International journal of environmental research and public health · 2014Article
- Practice variation across consent templates for biobank research. a survey of German biobanks.Frontiers in genetics · 2013Article
- Prevalence and sensitization of atopic allergy and coeliac disease in the Northern Sweden Population Health Study.International journal of circumpolar health · 2013Article
- Article
- Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids.American journal of human genetics · 2012Article
- Sequencing of high-complexity DNA pools for identification of nucleotide and structural variants in regions associated with complex traits.European journal of human genetics : EJHG · 2012Article
- Copy number variation across European populations.PloS one · 2011Article
- Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels.PLoS genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Family-based research in genetically isolated populations is an effective approach for identifying loci influencing variation in disease traits. In common with all studies in humans, those in genetically isolated populations need ethical approval; however, existing ethical frameworks may be inadequate to protect participant privacy and confidentiality and to address participants' information needs in such populations. Using the ethical-legal guidelines of the Council for International Organizations of Medical Sciences (CIOMS) as a template, we compared the participant information leaflets and consent forms of studies in five European genetically isolated populations to identify additional information that should be incorporated into information leaflets and consent forms to guarantee satisfactorily informed consent. We highlight the additional information that participants require on the research purpose and the reasons why their population was chosen; on the potential risks and benefits of participation; on the opportunities for benefit sharing; on privacy; on the withdrawal of consent and on the disclosure of genetic data. This research raises some important issues that should be addressed properly and identifies relevant types of information that should be incorporated into information leaflets for this type of study.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.