ArticleBritish journal of cancer2009
Familial association of pancreatic cancer with other malignancies in Swedish families.
Article in British journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Investigating the tissue specificity and prognostic impact of cis-regulatory cancer risk variants.Human genetics · 2023Article
- Review
- Intraductal Papillary Mucinous Neoplasms in Hereditary Cancer Syndromes.Biomedicines · 2022Review
- Pancreatic cancer risk to siblings of probands in bilineal cancer settings.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- Molecular Features and Clinical Management of Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer.International journal of molecular sciences · 2022Review
- Diabetes Mellitus, Obesity, and Risk of Pancreatic Ductal Adenocarcinoma: a Large Case-Control Study from Iran.Middle East journal of digestive diseases · 2021Article
- Use of relevancy and complementary information for discriminatory gene selection from high-dimensional gene expression data.PloS one · 2021Article
- BRCA Mutations in Pancreas Cancer: Spectrum, Current Management, Challenges and Future Prospects.Cancer management and research · 2020Review
- The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer.Cancer management and research · 2020Article
- The effects of a prior malignancy on the survival of patients with ovarian cancer: a population-based study.Journal of Cancer · 2020Article
- Familial association of lung cancer with liver cancer in first-degree relatives.Cancer management and research · 2019Article
- Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine.Cancer discovery · 2018Article
- The impact of a history of cancer on pancreatic ductal adenocarcinoma survival.United European gastroenterology journal · 2018Article
- Inherited pancreatic cancer.Chinese clinical oncology · 2017Review
- [Forecasting model of risk of cancer in lung cancer pedigree in a case-control study].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2011Article
- Familial pancreatic cancer.Cancers · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to characterise the familial association of pancreatic cancer with other malignancies.
methodsRelative risks (RRs) of pancreatic cancer according to family history of cancer were calculated using the updated Swedish Family-Cancer Database, which includes over 11.5 million individuals. Estimates were based on Poisson regression. RRs of tumours for individuals with a parental history of pancreatic cancer were also estimated.
resultsThe risk of pancreatic cancer was elevated in individuals with a parental history of cancers of the liver (RR 1.41; 95% CI 1.10-1.81), kidney (RR 1.37; 95% CI 1.06-1.76), lung (RR 1.50; 95% CI 1.27-1.79) and larynx (RR 1.98; 95% CI 1.19-3.28). Associations were also found between parental history of pancreatic cancer and cancers of the small intestine, colon, breast, lung, testis and cervix in offspring. There was an increased risk of pancreatic cancer associated with early-onset breast cancer in siblings.
conclusionPancreatic cancer aggregates in families with several types of cancer. Smoking may contribute to the familial aggregation of pancreatic and lung tumours, and the familial clustering of pancreatic and breast cancer could be partially explained by inherited mutations in the BRCA2 gene.
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