ArticleJournal of clinical gastroenterology2010
Long-term therapeutic outcome of patients undergoing ambulatory pH monitoring for chronic unexplained cough.
Article in Journal of clinical gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease.Chest · 2013Pooled it
- Latin American consensus on diagnosis of gastroesophageal reflux disease.Neurogastroenterology and motility · 2024Article
- The Utility of Symptom Association Probability (SAP) in Predicting Outcome After Laparoscopic Fundoplication in Patients with Abnormal Esophageal Acid Exposure.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Predictive value of clinical features for anti-reflux therapy response in suspected gastroesophageal reflux-induced chronic cough.Journal of thoracic disease · 2023Article
- Typical symptoms and not positive reflux-cough correlation predict cure of gastroesophageal reflux disease related chronic cough after laparoscopic fundoplication: a retrospective study.BMC gastroenterology · 2019Article
- Expert consensus document: Advances in the physiological assessment and diagnosis of GERD.Nature reviews. Gastroenterology & hepatology · 2017Review
- Proton Pump Inhibitors in Gastroesophageal Reflux Disease: Friend or Foe.Current gastroenterology reports · 2017Review
- GERD phenotypes from pH-impedance monitoring predict symptomatic outcomes on prospective evaluation.Neurogastroenterology and motility · 2016Observational
- Parameters on esophageal pH-impedance monitoring that predict outcomes of patients with gastroesophageal reflux disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Article
- Management of GERD-Related Chronic Cough.Gastroenterology & hepatology · 2013Article
- Assessment of concordance of symptom reflux association tests in ambulatory pH monitoring.Alimentary pharmacology & therapeutics · 2012Article
- High resolution manometry patterns distinguish acid sensitivity in non-cardiac chest pain.Neurogastroenterology and motility · 2011Article
- Clinical outcomes of atypical extra-esophageal reflux symptoms following laparoscopic antireflux surgery.Surgical endoscopy · 2011Article
- GERD-related cough: pathophysiology and diagnostic approach.Current gastroenterology reports · 2011Review
- The effect of antisecretory therapy and study duration on ambulatory esophageal pH monitoring.Digestive diseases and sciences · 2011Article
- Abnormal GERD parameters on ambulatory pH monitoring predict therapeutic success in noncardiac chest pain.The American journal of gastroenterology · 2010Article
- [Latin American Consensus on the Diagnosis of Gastroesophageal Reflux Disease].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimAmbulatory pH monitoring is frequently performed to determine temporal associations between reflux events and chronic unexplained cough. We further explored the clinical value of ambulatory pH monitoring in predicting long-term symptomatic outcome of therapy in chronic cough.
methodsSymptom scores and reflux indicators from ambulatory pH study [acid exposure time, symptom association probability (SAP), and symptom index] were extracted from records of subjects undergoing esophageal evaluation for chronic cough. Intensity of antireflux therapy administered and symptomatic outcome were determined by telephone interview. Univariate and logistic regression analysis were performed to identify predictors of a high degree response (HDR), defined as sustained, durable symptom improvement lasting >3 months.
resultsFifty-three subjects (mean age 63+/-2 y, 42 females) fulfilled the inclusion criteria. Reflux parameters were abnormal on ambulatory pH monitoring in 54.7%. After a mean interval of 3+/-0.3 years, cough intensity improved significantly, 19 subjects (35.8%) achieving HDR. Only female sex and positive SAP predicted HDR on univariate analysis; SAP and intensity of antireflux therapy were retained as independent predictors (P<or=0.03) on logistic regression analysis. Sequential use of acid exposure time, SAP, and symptom index had the best value, with the highest likelihood of HDR when all three were positive (85.7%, P<0.01).
conclusionsReflux disease is a frequent cause of chronic unexplained cough and aggressive antireflux therapy forms a vital component of management. Positive SAP is an independent predictor of outcome, but hierarchical or sequential use of abnormal gastroesophageal reflux disease parameters on ambulatory pH testing has value in predicting long-term symptomatic response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.