ReviewCurrent opinion in chemical biology2009
Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.
Review in Current opinion in chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Virtual cell: Current perspectives and future prospects.The Journal of international medical research · 2026Review
- Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects.Current issues in molecular biology · 2024Review
- Small molecule photocatalysis enables drug target identification via energy transfer.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- High Content Analysis Across Signaling Modulation Treatments for Subcellular Target Identification Reveals Heterogeneity in Cellular Response.Frontiers in cell and developmental biology · 2020Article
- Accelerating glioblastoma drug discovery: Convergence of patient-derived models, genome editing and phenotypic screening.Molecular and cellular neurosciences · 2017Review
- Real-Time Biological Annotation of Synthetic Compounds.Journal of the American Chemical Society · 2016Article
- Novel Vein Patterns in Arabidopsis Induced by Small Molecules.Plant physiology · 2016Article
- Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Trends in genetics : TIG · 2015Review
- Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.Journal of biomolecular screening · 2014Article
- Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Journal of biomolecular screening · 2014Article
- Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment.Journal of biomolecular screening · 2013Article
- Target identification and mechanism of action in chemical biology and drug discovery.Nature chemical biology · 2013Review
- Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers.Journal of medicinal chemistry · 2012Article
- Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A survey of yeast genomic assays for drug and target discovery.Pharmacology & therapeutics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Discovering small-molecule modulators for thousands of gene products requires multiple stages of biological testing, specificity evaluation, and chemical optimization. Many cellular profiling methods, including cellular sensitivity, gene expression, and cellular imaging, have emerged as methods to assess the functional consequences of biological perturbations. Cellular profiling methods applied to small-molecule science provide opportunities to use complex phenotypic information to prioritize and optimize small-molecule structures simultaneously against multiple biological endpoints. As throughput increases and cost decreases for such technologies, we see an emerging paradigm of using more information earlier in probe-discovery and drug-discovery efforts. Moreover, increasing access to public datasets makes possible the construction of 'virtual' profiles of small-molecule performance, even when multiplexed measurements were not performed or when multidimensional profiling was not the original intent. We review some key conceptual advances in small-molecule phenotypic profiling, emphasizing connections to other information, such as protein-binding measurements, genetic perturbations, and cell states. We argue that to maximally leverage these measurements in probe-discovery and drug-discovery requires a fundamental connection to synthetic chemistry, allowing the consequences of synthetic decisions to be described in terms of changes in small-molecule profiles. Mining such data in the context of chemical structure and synthesis strategies can inform decisions about chemistry procurement and library development, leading to optimal small-molecule screening collections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.