Evidence map›Paper›PMID 19825449›Full record

ReviewHematology/oncology clinics of North America2009

Cytogenetics and molecular genetics of acute lymphoblastic leukemia.

Krzysztof Mrózek, David P Harper, Peter D Aplan

Abstract readReview
In one paragraph

Review in Hematology/oncology clinics of North America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Krzysztof MrózekDivision of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, James Cancer Hospital, The Ohio State University, Room 1248B, 300 West Tenth Avenue, Columbus, OH 43210-1228, USA. krzysztof.mrozek@osumc.edu
David P Harper
Peter D Aplan

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Cancer and Leukemia Group B - Leukemia Correlative SciencesU10CA101140 · NCI · OHIO STATE UNIVERSITY · PI MARCUCCI, GUIDO · 2003 to 2013
$10.3M
Activation of Proto-Oncogenes by Chromosomal TranslocationZIASC010378 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$8.4M
Mutation Mechanisms Leading to Malignant Transformation, Including Chromosomal Translocation and Point MutationsZIASC010379 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$4.9M
Intramural NIH HHSNCI NIH HHS CA101140NCI NIH HHS CA16058NCI NIH HHS P30 CA016058NCI NIH HHS U10 CA101140
6 · The paper itself

Abstract

Acute lymphoblastic leukemia (ALL) is a malignant disease that often features nonrandom numerical or structural chromosome aberrations that can be detected microscopically. The application of contemporary genome-wide molecular analyses is revealing additional genetic alterations that are not detectable cytogenetically. This article describes the cytogenetic methodology and summarizes major cytogenetic findings and their clinical relevance in ALL. The article provides a review of modern molecular techniques and their application in the research on the genetics and epigenetics of ALL.

Indexed as

Chromosome AberrationsCytogenetic AnalysisCytogeneticsHumansMolecular BiologyPrecursor Cell Lymphoblastic Leukemia-Lymphoma

Identifiers

PMID19825449
PMCPMC3607311

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.