ArticleExperimental gerontology2010
Aged mice display an altered pulmonary host response to Francisella tularensis live vaccine strain (LVS) infections.
Article in Experimental gerontology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Chronically hypertensive transgenic mice expressing human AT1R haplotype-I exhibit increased susceptibility toFrontiers in microbiology · 2023Article
- Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses.Frontiers in immunology · 2022Article
- Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice.Aging and disease · 2021Article
- The Impact of Age and Sex on Mouse Models of Melioidosis.Pathogens (Basel, Switzerland) · 2020Article
- Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response.Intensive care medicine experimental · 2019Article
- Age Impacts Pulmonary Inflammation and Systemic Bone Response to Inhaled Organic Dust Exposure.Journal of toxicology and environmental health. Part A · 2015Article
- Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart.Immunology letters · 2014Review
- The aging lung.Clinical interventions in aging · 2013Review
- Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models.Aging and disease · 2011Article
- A galU mutant of Francisella tularensis is attenuated for virulence in a murine pulmonary model of tularemia.BMC microbiology · 2011Article
- Article
- P4 peptide therapy rescues aged mice from fatal pneumococcal sepsis.Clinical and vaccine immunology : CVI · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Aging is a complex phenomenon that has been shown to affect many organ systems including the innate and adaptive immune systems. The current study was designed to examine the potential effect of immunosenescence on the pulmonary immune response using a Francisella tularensis live vaccine strain (LVS) inhalation infection model. F. tularensis is a Gram-negative intracellular pathogen that can cause a severe pneumonia. In this study both young (8-12 week old) and aged (20-24 month old) mice were infected intranasally with LVS. Lung tissues from young and aged mice were used to assess pathology, recruitment of immune cell types and cytokine expression levels at various times post infection. Bacterial burdens were also assessed. Interestingly, the lungs of aged animals harbored fewer organisms at early time points of infection (day 1, day 3) compared with their younger counterparts. In addition, only aged animals displayed small perivascular aggregates at these early time points that appeared mostly mononuclear in nature. However, the kinetics of infiltrating polymorphonuclear neutrophils (PMNs) and increased cytokine levels measured in the bronchial alveolar lavage fluid (BALF) were delayed in infected aged animals relative to young infected animals with neutrophils appearing at day 5 post infection (PI) in the aged animals as opposed to day 3 PI in the young infected animals. Also evident were alterations in the ratios of mononuclear to PMNs at distinct post infection times. The above evidence indicates that aged mice elicit an altered immune response in the lung to respiratory F. tularensis LVS infections compared to their younger counterparts.
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