ArticleBreast cancer research : BCR2009
Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study.
Article in Breast cancer research : BCR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 49 citations in OpenAlex.
- Impact ofCancers · 2024Article
- Heterogeneity of the tumor immune microenvironment and clinical interventions.Frontiers of medicine · 2023Review
- Mechanisms of breast cancer metastasis.Clinical & experimental metastasis · 2022Review
- The role of SIPA1 in the development of cancer and metastases (Review).Molecular and clinical oncology · 2020Review
- The second genome: Effects of the mitochondrial genome on cancer progression.Advances in cancer research · 2019Article
- Genetic insights into the morass of metastatic heterogeneity.Nature reviews. Cancer · 2018Review
- Integration of biomimicry and nanotechnology for significantly improved detection of circulating tumor cells (CTCs).Advanced drug delivery reviews · 2018Review
- Mitochondrial Haplotype Alters Mammary Cancer Tumorigenicity and Metastasis in an Oncogenic Driver-Dependent Manner.Cancer research · 2017Article
- The Clock Is Ticking: Countdown to Metastases.PLoS genetics · 2016Article
- The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer.PLoS genetics · 2016Article
- An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.PLoS genetics · 2016Article
- The role of individual inheritance in tumor progression and metastasis.Journal of molecular medicine (Berlin, Germany) · 2015Review
- The SIPA1 -313A>G polymorphism is associated with prognosis in inoperable non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Prediction of breast cancer survival using clinical and genetic markers by tumor subtypes.PloS one · 2015Article
- Molecular signatures of lymph node status by intrinsic subtype: gene expression analysis of primary breast tumors from patients with and without metastatic lymph nodes.Journal of experimental & clinical cancer research : CR · 2014Article
- Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation.Molecular cancer research : MCR · 2014Article
- RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1.Oncogene · 2014Article
- Time-dependent risk of developing distant metastasis in breast cancer patients according to treatment, age and tumour characteristics.British journal of cancer · 2014Article
- Understanding susceptibility to breast cancer metastasis: the genetic approach.Breast cancer management · 2014Article
- An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease.Genome research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionPrevious studies in mouse models and pilot epidemiology studies have demonstrated that inherited polymorphisms are associated with inherited risk of tumor progression and poor outcome in human breast cancer. To extend these studies and gain better understanding of the function of inherited polymorphism in breast cancer progression, a validation prognosis study was performed in a large independent breast cancer patient population.
methodsThe study population consisted of 1863 Dutch patients with operable primary breast cancer from Rotterdam, The Netherlands. Genomic DNA was genotyped for the missense Pro436Leu RRP1B single nucleotide polymorphism (SNP) rs9306160 and the intronic SIPA1 SNP rs2448490 by SNP-specific PCR.
resultsA significant association of variants in RRP1B with metastasis-free survival was observed (P = 0.012), validating the role of RRP1B with inherited metastatic susceptibility. Stratification of patients revealed that association with patients' survival was found to be specifically restricted to estrogen receptor positive, lymph node-negative (ER+/LN-) patients (P = 0.011). The specific association with metastasis-free survival only in ER+/LN- patients was replicated for SIPA1, a second metastasis susceptibility gene known to physically interact with RRP1B (P = 0.006). Combining the genotypes of these two genes resulted in the significant ability to discriminate patients with poor metastasis-free survival (HR: 0.40, 95% CI: 0.24 to 0.68, P = 0.001).
conclusionsThese results validate SIPA1 and RRP1B as metastasis susceptibility genes and suggest that genotyping assays may be a useful supplement to other clinical and molecular indicators of prognosis. The results also suggest that lymphatic and hematogeneous metastases are genetically distinct that may involve different mechanisms. If true, these results suggest that metastatic disease, like primary breast cancer, may be multiple diseases and that stratification of late stage patients may therefore be required to fully understand breast cancer progression and metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.