Evidence map›Paper›PMID 19825173›Full record

ArticleGenome biology2009

Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels.

Ian Sudbery, Jim Stalker, Jared T Simpson, Thomas Keane, Alistair G Rust, Matthew E Hurles, Klaudia Walter, Dee Lynch, Lydia Teboul, Steve D Brown and 6 more

Open access · goldAbstract read
In one paragraph

Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The Mouse Genomes Project: a repository of inbred laboratory mouse strain genomes.Mammalian genome : official journal of the International Mammalian Genome Society · 2015
    Article
  6. PWD/PhJ mice have a genetically determined increase in nutrient-stimulated insulin secretion.Mammalian genome : official journal of the International Mammalian Genome Society · 2015
    Article
  7. Article
  8. Advances in genomics of bony fish.Briefings in functional genomics · 2014
    Review
  9. Genetic resistance to liver fibrosis on A/J mouse chromosome 17.Alcoholism, clinical and experimental research · 2013
    Article
  10. Article
  11. CNVeM: copy number variation detection using uncertainty of read mapping.Journal of computational biology : a journal of computational molecular cell biology · 2013
    Article
  12. Chromosomes in the flow to simplify genome analysis.Functional & integrative genomics · 2012
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Mouse chromosome 17 candidate modifier genes for thrombosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2010
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Ian SudberyThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1HH, UK. ims@sanger.ac.uk
Jim Stalker
Jared T Simpson
Thomas Keane
Alistair G Rust
Matthew E Hurles
Klaudia Walter
Dee Lynch
Lydia Teboul
Steve D Brown
Heng Li
Zemin Ning
Joseph H Nadeau
Colleen M Croniger
Richard Durbin
David J Adams
Wellcome Sanger Institute · GBMary Lyon Centre at MRC Harwell · GBCase Western Reserve University · US

Funding

Pilot ProjectP20AA017837 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI NAGY, LAURA E. · 2009 to 2013
$2.2M
Cancer Research UKMedical Research Council G0800024Medical Research Council MC_UP_1502/1NIAAA NIH HHS P20 AA017837Wellcome Trust
6 · The paper itself

Abstract

Genome sequences are essential tools for comparative and mutational analyses. Here we present the short read sequence of mouse chromosome 17 from the Mus musculus domesticus derived strain A/J, and the Mus musculus castaneus derived strain CAST/Ei. We describe approaches for the accurate identification of nucleotide and structural variation in the genomes of vertebrate experimental organisms, and show how these techniques can be applied to help prioritize candidate genes within quantitative trait loci.

Indexed as

AnimalsBase SequenceChromosomes, MammalianCodon, TerminatorGene DosageGenomeGerm-Line MutationLiverMajor Histocompatibility ComplexMiceMice, Inbred StrainsPolymorphism, Single NucleotideQuality ControlQuantitative Trait LociReference StandardsRNA, MessengerCodon, TerminatorRNA, MessengerTriglycerides

Identifiers

PMID19825173
PMCPMC2784327
OpenAlexW2106510321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.