ArticleBehavioral neuroscience2009
Factors governing single-trial contextual fear conditioning in the weanling rat.
Article in Behavioral neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats.Behavioral neuroscience · 2023Article
- The effects of early-life immune activation on microglia-mediated neuronal remodeling and the associated ontogeny of hippocampal-dependent learning in juvenile rats.Brain, behavior, and immunity · 2021Article
- NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning.Developmental psychobiology · 2020Article
- Sensorimotor developmental factors influencing the performance of laboratory rodents on learning and memory.Behavioural brain research · 2019Review
- Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.Behavioral neuroscience · 2018Article
- Differential expression of the immediate early genes c-Fos, Arc, Egr-1, and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats.Developmental neurobiology · 2017Article
- Differential involvement of the medial prefrontal cortex across variants of contextual fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Understanding the contributions of visual stimuli to contextual fear conditioning: A proof-of-concept study using LCD screens.Neuroscience letters · 2017Article
- Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.Behavioral neuroscience · 2016Article
- Variants of contextual fear conditioning induce differential patterns of Egr-1 activity within the young adult prefrontal cortex.Behavioural brain research · 2016Article
- NMDA receptor antagonism disrupts acquisition and retention of the context preexposure facilitation effect in adolescent rats.Behavioural brain research · 2016Article
- Using the context preexposure facilitation effect to study long-term context memory in preweanling, juvenile, adolescent, and adult rats.Physiology & behavior · 2015Article
- Contextual and auditory fear conditioning continue to emerge during the periweaning period in rats.PloS one · 2014Article
- Egr-1 increases in the prefrontal cortex following training in the context preexposure facilitation effect (CPFE) paradigm.Neurobiology of learning and memory · 2013Article
- Determinants of novel object and location recognition during development.Behavioural brain research · 2013Article
- Role of age, post-training consolidation, and conjunctive associations in the ontogeny of the context preexposure facilitation effect.Developmental psychobiology · 2012Article
- Effects of dose and period of neonatal alcohol exposure on the context preexposure facilitation effect.Alcoholism, clinical and experimental research · 2011Article
- Ontogeny and neural substrates of the context preexposure facilitation effect.Neurobiology of learning and memory · 2011Article
- Variants of contextual fear conditioning are differentially impaired in the juvenile rat by binge ethanol exposure on postnatal days 4-9.Behavioural brain research · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Although contextual fear conditioning emerges later in development than explicit-cue fear conditioning, little is known about the stimulus parameters and biological substrates required at early ages. The authors adapted methods for investigating hippocampus function in adult rodents to identify determinants of contextual fear conditioning in developing rats. Experiment 1 examined the duration of exposure required by weanling rats at postnatal day (PND) 23 to demonstrate contextual fear conditioning. This experiment demonstrated that 30 s of context exposure is sufficient to support conditioning. Furthermore, preexposure enhanced conditioning to an immediate footshock, the context preexposure facilitation effect (CPFE), but had no effect on contextual conditioning to a delayed shock. Experiment 2 demonstrated that N-methyl-D-aspartate (NMDA) receptor inactivation during preexposure impairs contextual learning at PND 23. Thus, the conjuctive representations underlying the CPFE are NMDA-dependent as early as PND23 in the rat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.