ArticleWorld journal of gastroenterology2009
Effect of Lonicerae Flos extracts on reflux esophagitis with antioxidant activity.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- The Efficacy and Safety of GCWB104 (Gut and liver · 2020Trial
- Natural Products in the Management of Gastroesophageal Reflux Disease: Mechanisms, Efficacy, and Future Directions.Nutrients · 2025Review
- Columbianadin ameliorates experimental acute reflux esophagitis in rats via suppression of NF-κB pathway.Acta cirurgica brasileira · 2024Article
- Scutellariae Radix and Citri Reticulatae Pericarpium Mixture Regulate PPAREvidence-based complementary and alternative medicine : eCAM · 2022Article
- The In Vitro and In Vivo Synergistic Antimicrobial Activity Assessment of Vacuum Microwave Assisted Aqueous Extracts from Pomegranate and Avocado Fruit Peels and Avocado Seeds Based on a Mixtures Design Model.Plants (Basel, Switzerland) · 2021Article
- Protective Effects of Korean Herbal Remedy against Airway Inflammation in an Allergic Asthma by Suppressing Eosinophil Recruitment and Infiltration in Lung.Antioxidants (Basel, Switzerland) · 2020Article
- Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review.Frontiers in pharmacology · 2020Review
- De novo transcriptomic analysis of light-induced flavonoid pathway, transcription factors in the flower buds ofTrees (Berlin, Germany : West) · 2020Article
- Anti-ulcer effect of Gallarhois extract with anti-oxidant activity in an ICR model of ethanol/hydrochloride acid-induced gastric injury.Journal of traditional and complementary medicine · 2019Article
- Popular Remedies for Esophageal Symptoms: a Critical Appraisal.Current gastroenterology reports · 2019Review
- Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors.BMC plant biology · 2019Article
- Protective effects of triple fermented barley extract (FBe) on indomethacin-induced gastric mucosal damage in rats.BMC complementary and alternative medicine · 2019Article
- Protective effects of a triple-fermented barley extract (FBe) against HCl/EtOH-induced gastric mucosa damage in mice.Food science & nutrition · 2018Article
- Effects of Platycodin D on Reflux Esophagitis due to Modulation of Antioxidant Defense Systems.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Huangqin-Tang and Ingredients in Modulating the Pathogenesis of Ulcerative Colitis.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- De novo transcriptome assembly and characterization of nine tissues of Lonicera japonica to identify potential candidate genes involved in chlorogenic acid, luteolosides, and secoiridoid biosynthesis pathways.Journal of natural medicines · 2017Article
- Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice.Experimental and therapeutic medicine · 2016Article
- Comparison of the response using ICR mice derived from three different sources to ethanol/hydrochloric acid-induced gastric injury.Laboratory animal research · 2016Article
- Article
- Effect of phosphorus deficiency on photosynthetic inorganic carbon assimilation of three climber plant species.Botanical studies · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo observe the effects of traditional antiinflammatory medicine Lonicerae Flos (LF) on rat reflux esophagitis (RE) induced by pylorus and forestomach ligation compared with the well-known proton antioxidant, alpha-tocopherol.
methodsRats were pretreated with three different dosages of LF (500, 250 and 125 mg/kg) orally, once a day for 14 d before pylorus and forestomach ligation. Nine hours after pylorus and forestomach ligation, changes to the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), myeloperoxidase and glutathione (GSH) levels, and collagen contents (marker of flexibility) were observed on the esophageal and fundic histopathology. The results were compared with an alpha-tocopherol (once orally, 1 h before operation, 30 mg/kg) treated group in which the effects on RE were already confirmed.
resultsPylorus and forestomach ligations caused marked increases of gross esophageal and gastric mucosa lesion areas, which corresponded with histopathological changes. In addition, increases of esophageal lipid peroxidation, decreases of SOD, CAT, and GSH-free radical scavengers, increases of collagen were observed. However, these pylorus and forestomach ligation induced RE were dose-dependently inhibited by treatment of 500, 250 and 125 mg/kg of LF extract, mediated by antioxidant effects. RE at 250 mg/kg showed similar effects alpha-tocopherol.
conclusionThe results suggest that antioxidant effects of LF could attenuate the severity of RE and prevent the esophageal mucosal damage, and validate its therapeutic use in esophageal reflux disease.
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