ArticleWorld journal of gastroenterology2009
Long-term treatment with proton pump inhibitor is associated with undesired weight gain.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Forgettable in the care of liver cirrhosis: the unseen culprits of progression from bad to worse.Przeglad gastroenterologiczny · 2024Review
- Fatty liver and celiac disease: Why worry?World journal of hepatology · 2023Review
- When does proton pump inhibitor treatment become long term? A scoping review.BMJ open gastroenterology · 2021Article
- A comprehensive diagnostic approach to detect underlying causes of obesity in adults.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019Review
- Extensive Phenotyping for Potential Weight-Inducing Factors in an Outpatient Population with Obesity.Obesity facts · 2019Observational
- Proton pump inhibitors as risk factor for metabolic syndrome and hepatic steatosis in coeliac disease patients on gluten-free diet.Journal of gastroenterology · 2018Observational
- Gut microbiome diversity and high-fibre intake are related to lower long-term weight gain.International journal of obesity (2005) · 2017Article
- Weight gain in mice on a high caloric diet and chronically treated with omeprazole depends on sex and genetic background.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Significant obesity-associated gene expression changes occur in the stomach but not intestines in obese mice.Physiological reports · 2016Article
- Association of Proton Pump Inhibitor (PPI) Use with Energy Intake, Physical Activity, and Weight Gain.Nutrients · 2015Article
- Do proton pump inhibitors contribute to weight gain?Obesity surgery · 2015Article
- Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice.PloS one · 2015Article
- The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass.Obesity surgery · 2014Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the effects of long-term proton pump inhibitor (PPI) therapy on body weight (BW) and body mass index (BMI) in patients with gastroesophageal reflux disease (GERD).
methodsThe subjects were 52 patients with GERD and 58 sex- and age-matched healthy controls. GERD patients were treated with PPI for a mean of 2.2 years (range, 0.8-5.7 years), and also advised on lifestyle modifications (e.g. selective diet, weight management). BW, BMI and other parameters were measured at baseline and end of study.
resultsTwenty-four GERD patients were treated daily with 10 mg omeprazole, 12 with 20 mg omeprazole, 8 with 10 mg rabeprazole, 5 with 15 mg lansoprazole, and 3 patients with 30 mg lansoprazole. At baseline, there were no differences in BW and BMI between reflux patients and controls. Patients with GERD showed increases in BW (baseline: 56.4 +/- 10.4 kg, end: 58.6 +/- 10.8 kg, mean +/- SD, P < 0.0001) and BMI (baseline: 23.1 +/- 3.1 kg/m(2), end: 24.0 +/- 3.1 kg/m(2), P < 0.001), but no such changes were noted in the control group. Mean BW increased by 3.5 kg (6.2% of baseline) in 37 (71%) reflux patients but decreased in only 6 (12%) patients during treatment.
conclusionLong-term PPI treatment was associated with BW gain in patients with GERD. Reflux patients receiving PPI should be encouraged to manage BW through lifestyle modifications.
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