ArticleJournal of neurology2010
A comparison of three measures of upper limb function in Friedreich ataxia.
Article in Journal of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04740359 (The Effect of Functional Trunk Training on Trunk Control and Upper Extremity Functions in Hereditary Ataxia Patients With Autosomal Recessive), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Functional Trunk Training on Trunk Control and Upper Extremity Functions in Hereditary Ataxia Patients With Autosomal Recessive
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Digital Motor Outcomes Capture Upper Limb and Mild Stage Impairment in Hereditary Spastic Paraplegia.Neurology and therapy · 2026Article
- iPatax: a Tablet-based Tool for Quantitative Assessment of Cerebellar Ataxia.Cerebellum (London, England) · 2026Article
- Digital Outcomes of Upper Limb Ataxia Capture Meaningful Longitudinal Change and Treatment Response.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Clinical and cognitive assessment in Friedreich ataxia clinical trials: a review.Frontiers in neurology · 2025Review
- Anatomical and functional analysis of the corticospinal tract in an FRDA mouse model.bioRxiv : the preprint server for biology · 2024Article
- Multifeature quantitative motor assessment of upper limb ataxia including drawing and reaching.Annals of clinical and translational neurology · 2024Article
- Friedreich ataxia: clinical features and new developments.Neurodegenerative disease management · 2022Review
- Upper Body Physical Rehabilitation for Children with Ataxia through IMU-Based Exergame.Journal of clinical medicine · 2022Article
- Digital endpoints for self-administered home-based functional assessment in pediatric Friedreich's ataxia.Annals of clinical and translational neurology · 2021Article
- Developing an Instrumented Measure of Upper Limb Function in Friedreich Ataxia.Cerebellum (London, England) · 2021Article
- Hand Dexterity and Pyramidal Dysfunction in Friedreich Ataxia, A Finger Tapping Study.Movement disorders clinical practice · 2021Article
- Measurements of Hand Function in Degenerative Cerebellar Disease: A Case-Control Pilot Study.American journal of physical medicine & rehabilitation · 2020Article
- Developing an objective evaluating system to quantify the degree of upper limb movement impairment in patients with severe Friedreich's ataxia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Application of Quantitative Motor Assessments in Friedreich Ataxia and Evaluation of Their Relation to Clinical Measures.Cerebellum (London, England) · 2019Article
- How does performance of the Friedreich Ataxia Functional Composite compare to rating scales?Journal of neurology · 2017Article
- Robotic and clinical evaluation of upper limb motor performance in patients with Friedreich's Ataxia: an observational study.Journal of neuroengineering and rehabilitation · 2015Observational
- Excessive motor overflow reveals abnormal inter-hemispheric connectivity in Friedreich ataxia.Journal of neurology · 2013Article
- Measures of fine motor skills in people with tremor disorders: appraisal and interpretation.Frontiers in neurology · 2013Article
- Longitudinal change in dysarthria associated with Friedreich ataxia: a potential clinical endpoint.Journal of neurology · 2012Article
- A novel deletion-insertion mutation identified in exon 3 of FXN in two siblings with a severe Friedreich ataxia phenotype.Neurogenetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Friedreich Ataxia (FRDA) is the commonest inherited ataxia. Clinical trials of pharmaceuticals are increasingly being conducted in this condition. This requires the most accurate outcome measures to enable trials to be conducted with a minimum number of subjects in the shortest time frame and to minimize the risk of false negative results. Upper limb function is a major area of morbidity in FRDA. We therefore have compared the performance of three tests of upper limb function in FRDA: the Nine Hole Peg Test (9HPT), Box and Blocks Test (BBT) and Jebsen Taylor Hand Function Test (JTHFT). This study was undertaken to ascertain the best test for inclusion in a Friedreich Ataxia Functional Composite (FAFC) test for use in clinical studies and therapeutic trials. The three tests were administered to the dominant and non-dominant upper limbs of 38 individuals with genetically proven FRDA on two occasions, 12 months apart. The results of testing were correlated with the following disease parameters; age at disease onset, disease duration and score for the Friedreich Ataxia Rating Scale (FARS). The responsiveness to change of each test was assessed by measuring the effect size and calculations of the number of subjects required for similarly powered therapeutic trials. Results for all tests correlated significantly with disease duration and FARS score. The only test scores that changed significantly over 12 months were those for the non-dominant 9HPT and BBT. Scores for these two tests also had the largest effect sizes and required the fewest subjects for similarly powered therapeutic trials. We conclude, therefore, that the non-dominant 9HPT and BBT are the best tests for inclusion in a FAFC. Since the 9HPT has already been suggested for inclusion in a FAFC, we recommend that this test is used but that it is the non-dominant limb that is tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.