ArticlePflugers Archiv : European journal of physiology2010
The puzzling role of TRPC3 channels in motor coordination.
Article in Pflugers Archiv : European journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Pathophysiological significance and modulation of the transient receptor potential canonical 3 ion channel.Medicinal research reviews · 2024Review
- A role for TRPC3 in mammalian testis development.Frontiers in cell and developmental biology · 2024Article
- Spinocerebellar ataxias (SCAs) caused by common mutations.Neurogenetics · 2021Review
- Canonical Transient Receptor Potential (TRPC) Channels in Nociception and Pathological Pain.Neural plasticity · 2020Review
- Mechanotransduction in the muscle spindle.Pflugers Archiv : European journal of physiology · 2015Review
- The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.Cerebellum (London, England) · 2014Review
- In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels -- mirage or pot of gold?British journal of pharmacology · 2013Review
- Trpc2 depletion protects red blood cells from oxidative stress-induced hemolysis.Experimental hematology · 2012Article
- The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin.The Journal of biological chemistry · 2011Article
- PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity.BMC developmental biology · 2010Article
- International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family.Pharmacological reviews · 2010Review
- TRPC channels in smooth muscle cells.Frontiers in bioscience (Landmark edition) · 2010Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Transient receptor potential canonical 3 (TRPC3) proteins are nonselective cation channels activated downstream of phospholipase-C-coupled receptors. TRPC3 channels have emerged as major players in the function of the central nervous system. They have been described as important contributors to brain-derived neurotrophic factor mediated survival and growth-cone guidance of cerebellar granule neurons. TRPC3 were also identified as postsynaptic cation channels essential for metabotropic glutamate receptor1-dependent synaptic transmission in cerebellar Purkinje neurons. A recent report described motor coordination defects in TRPC3 knockout mice while a subsequent study reported a similar phenotype in so-called moonwalker mice, harboring a TRPC3 gain-of-function mutation. How can opposing aspects of TRPC3 channel activation lead to the same phenotype? Here we discuss the salient features of TRPC3 knockout mice and moonwalker mice and attempt to reconcile the apparently conflicting findings from these two animal models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.