Evidence map›Paper›PMID 19822887›Full record

ReviewClinical microbiology reviews2009

Innate immunity to Aspergillus species.

Stacy J Park, Borna Mehrad

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Immune interaction betweenFrontiers in cellular and infection microbiology · 2026
    Article
  7. Article
  8. Article
  9. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  10. Article
  11. Characterization of extracellular chitin deacetylase fromCurrent research in microbial sciences · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Interplay of Cytokines and Chemokines in Aspergillosis.Journal of fungi (Basel, Switzerland) · 2024
    Review
  17. Aspergillus and the Lung.Seminars in respiratory and critical care medicine · 2024
    Review
  18. Accelerating the understanding ofCurrent research in microbial sciences · 2024
    Review
  19. mSphere · 2023
    Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stacy J ParkDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia, P.O. Box 800546, Charlottesville, VA 22908, USA.
Borna Mehrad

Funding

NK cells in host defense against invasive aspergillosisR01HL073848 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA · 2003 to 2013
$3.3M
NHLBI NIH HHS HL73848NHLBI NIH HHS R01 HL073848
6 · The paper itself

Abstract

All humans are continuously exposed to inhaled Aspergillus conidia, yet healthy hosts clear the organism without developing disease and without the development of antibody- or cell-mediated acquired immunity to this organism. This suggests that for most healthy humans, innate immunity is sufficient to clear the organism. A failure of these defenses results in a uniquely diverse set of illnesses caused by Aspergillus species, which includes diseases caused by the colonization of the respiratory tract, invasive infection, and hypersensitivity. A key concept in immune responses to Aspergillus species is that the susceptibilities of the host determine the morphological form, antigenic structure, and physical location of the fungus. In this review, we summarize the current literature on the multiple layers of innate defenses against Aspergillus species that dictate the outcome of this host-microbe interaction.

Indexed as

AnimalsAspergillosisAspergillusHost-Pathogen InteractionsHumansImmunity, Innate

Identifiers

PMID19822887
PMCPMC2772361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.