Evidence map›Paper›PMID 19822873›Full record

GuidelineNeurology2009

Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.

R G Miller, C E Jackson, E J Kasarskis, J D England, D Forshew, W Johnston, S Kalra, J S Katz, H Mitsumoto, J Rosenfeld and 4 more

Registry-linked trialOpen access · bronzeAbstract readPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03604822 (Measuring the Effects of a Music Therapy Protocol on Respiratory and Bulbar Functions of Patients With Early and Mid-stage Amyotrophic Lateral Sclerosis), which is not on this map. Cited by 219 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 6 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03604822 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Measuring the Effects of a Music Therapy Protocol on Respiratory and Bulbar Functions of Patients With Early and Mid-stage Amyotrophic Lateral Sclerosis: Mixed Methods Single Case Study Series

TypeinterventionalSponsorAlisa AprelevaRan2017 to 2020Enrolled8ConditionsMotor Neuron Disease, Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis), Dysarthria, Flaccid, Dysarthria, SpasticArmsMusic therapy
3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 6 syntheses or guidelines pooled it, 653 citations in OpenAlex.

  1. Efficacy of pain management strategies in adults with Amyotrophic Lateral Sclerosis (ALS): A Systematic Review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Multidisciplinary care in Amyotrophic Lateral Sclerosis: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  6. Canadian best practice recommendations for the management of amyotrophic lateral sclerosis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020
    Guideline
  7. Trial
  8. Trial
  9. Patient-reported problematic symptoms in an ALS treatment trial.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2016
    Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Medical nutrition therapy for ALS: Dietitians' approaches to diagnosing malnutrition, facilitating feeding tube discussions, and mitigating refeeding syndrome risk.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Article
  19. Introduction to the Supplement.Muscle & nerve · 2026
    Article
  20. Review

159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

R G MillerDepartment of Neurology, California Pacific Medical Center, San Francisco, California, USA.
C E Jackson
E J Kasarskis
J D England
D Forshew
W Johnston
S Kalra
J S Katz
H Mitsumoto
J Rosenfeld
C Shoesmith
M J Strong
S C Woolley
Quality Standards Subcommittee of the American Academy of Neurology
The University of Texas Health Science Center at San Antonio · US

Funding

Clinical Trial of Ceftriaxone in Subjects with ALSU01NS049640 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CUDKOWICZ, MERIT E · 2006 to 2012
$37.7M
Thymectomy in Non-Thymomatous MG Patients on PrednisoneU01NS042685 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUTTER, GARY R · 2005 to 2015
$11.7M
Early Treatment of ALS with Nutrition and NIPPVR01NS045087 · NINDS · UNIVERSITY OF KENTUCKY · PI KASARSKIS, EDWARD JOSEPH · 2004 to 2007
$4.1M
Phase III Trial of Minocycline in ALS-II Data CenterR01NS044887 · NINDS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI MILLER, ROBERT G · 2003 to 2007
$1.7M
NATIONAL REGISTRY FOR MYOTONIC DYSTROPHY-264002250N01AR002250 · NIAMS · UNIVERSITY OF ROCHESTER · 2000 to 2004
$437k
NIAMS NIH HHS N01-AR-2250NINDS NIH HHS 1U01 NS049640NINDS NIH HHS R01-NS045087NINDS NIH HHS R01NS045087-01A2NINDS NIH HHS R01 NS 44887NINDS NIH HHS U01NS042685-0
6 · The paper itself

Abstract

objectiveTo systematically review evidence bearing on the management of patients with amyotrophic lateral sclerosis (ALS).

methodsThe authors analyzed studies from 1998 to 2007 to update the 1999 practice parameter. Topics covered in this section include breaking the news, multidisciplinary clinics, symptom management, cognitive and behavioral impairment, communication, and palliative care for patients with ALS.

resultsThe authors identified 2 Class I studies, 8 Class II studies, and 30 Class III studies in ALS, but many important areas have been little studied. More high-quality, controlled studies of symptomatic therapies and palliative care are needed to guide management and assess outcomes in patients with ALS. RECOMMENDATIONS: Multidisciplinary clinic referral should be considered for managing patients with ALS to optimize health care delivery and prolong survival (Level B) and may be considered to enhance quality of life (Level C). For the treatment of refractory sialorrhea, botulinum toxin B should be considered (Level B) and low-dose radiation therapy to the salivary glands may be considered (Level C). For treatment of pseudobulbar affect, dextromethorphan and quinidine should be considered if approved by the US Food and Drug Administration (Level B). For patients who develop fatigue while taking riluzole, withholding the drug may be considered (Level C). Because many patients with ALS demonstrate cognitive impairment, which in some cases meets criteria for dementia, screening for cognitive and behavioral impairment should be considered in patients with ALS (Level B). Other management strategies all lack strong evidence.

Indexed as

Patient Care TeamAmyotrophic Lateral SclerosisCognition DisordersDementiaEvidence-Based MedicineFatigueHumansMuscle CrampPalliative CarePseudobulbar PalsySialorrheaTerminal CareTruth Disclosure

Identifiers

PMID19822873
PMCPMC2764728
OpenAlexW1983734876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.