ArticleProceedings of the National Academy of Sciences of the United States of America2009
Regulative recovery in the sea urchin embryo and the stabilizing role of fail-safe gene network wiring.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Bacterial artificial chromosomes as recombinant reporter constructs to investigate gene expression and regulation in echinoderms.Briefings in functional genomics · 2018Review
- Paleogenomics of echinoids reveals an ancient origin for the double-negative specification of micromeres in sea urchins.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Evolutionary rewiring of gene regulatory network linkages at divergence of the echinoid subclasses.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Specific functions of the Wnt signaling system in gene regulatory networks throughout the early sea urchin embryo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Gene regulatory control in the sea urchin aboral ectoderm: spatial initiation, signaling inputs, and cell fate lockdown.Developmental biology · 2013Article
- Evo-devo in the era of gene regulatory networks.Integrative and comparative biology · 2012Article
- Evolutionary bioscience as regulatory systems biology.Developmental biology · 2011Article
- Regeneration in the era of functional genomics and gene network analysis.The Biological bulletin · 2011Article
- Wnt6 activates endoderm in the sea urchin gene regulatory network.Development (Cambridge, England) · 2011Article
- Evolutionary crossroads in developmental biology: sea urchins.Development (Cambridge, England) · 2011Review
- Modularity and design principles in the sea urchin embryo gene regulatory network.FEBS letters · 2009Review
- Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory network states.Wiley interdisciplinary reviews. Developmental biologyReview
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2 authors.
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Abstract
Design features that ensure reproducible and invariant embryonic processes are major characteristics of current gene regulatory network models. New cis-regulatory studies on a gene regulatory network subcircuit activated early in the development of the sea urchin embryo reveal a sequence of encoded "fail-safe" regulatory devices. These ensure the maintenance of fate separation between skeletogenic and nonskeletogenic mesoderm lineages. An unexpected consequence of the network design revealed in the course of these experiments is that it enables the embryo to "recover" from regulatory interference that has catastrophic effects if this feature is disarmed. A reengineered regulatory system inserted into the embryo was used to prove how this system operates in vivo. Genomically encoded backup control circuitry thus provides the mechanism underlying a specific example of the regulative development for which the sea urchin embryo has long been famous.
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