ArticleProceedings of the National Academy of Sciences of the United States of America2010
Colloquium papers: Heritability of reproductive fitness traits in a human population.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Genome-wide meta-analysis of common variant differences between men and women.Human molecular genetics · 2012Pooled it
- The legacy of privilege: Social inheritance reverses sex differences in reproductive inequality in the spotted hyena.Science advances · 2026Article
- Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish.Scientific reports · 2025Article
- Article
- What is driving the global decline of human fertility? Need for a multidisciplinary approach to the underlying mechanisms.Frontiers in reproductive health · 2024Review
- The Role of Genome Sequencing in Neonatal Intensive Care Units.Annual review of genomics and human genetics · 2022Review
- Women's lifetime reproductive profiles and frailty among aging individuals in the USA and the Philippines.Journal of physiological anthropology · 2022Review
- A reexamination of theoretical arguments that indirect selection on mate preference is likely to be weaker than direct selection.Evolution letters · 2022Article
- Lower total motile count is associated with smaller historic intergenerational family size: a pedigree analysis from the Utah Population Database.Journal of assisted reproduction and genetics · 2021Article
- The Origin of Additive Genetic Variance Driven by Positive Selection.Molecular biology and evolution · 2020Article
- Family Size and Educational Attainment: Cousins, Contexts, and Compensation.European journal of population = Revue europeenne de demographie · 2020Article
- Genetic variation in health insurance coverage.International journal of health economics and management · 2019Article
- Estimating variance components in population scale family trees.PLoS genetics · 2019Article
- An Ancient Fecundability-Associated Polymorphism Creates a GATA2 Binding Site in a Distal Enhancer of HLA-F.American journal of human genetics · 2018Article
- Limitations and opportunities in male fertility databases.Translational andrology and urology · 2018Review
- Complex genetics of female fertility.NPJ genomic medicine · 2018Review
- Article
- Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits.Genetics · 2017Article
- Article
- An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression.American journal of human genetics · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The genetic basis of fitness traits has been studied widely in animals, yet the contribution of genetic variation to these traits in humans is controversial. In particular, it is difficult to disentangle genetic versus environmental effects on fertility, because of within-family correlations of sociocultural, economic, and other nongenetic factors that influence family sizes. In this study, we investigated the genetic architecture of reproductive fitness traits in a fertile human population whose communal lifestyle assures uniform and equal access to resources. Our study revealed significant heritabilities for reproductive traits in both men and women, after accounting for common household effects shared among siblings and demographic changes in reproductive practices. Furthermore, our results indicate that both autosomal and X-linked additive and dominance variances contribute to these traits. We therefore propose that reproductive traits should be amenable to genetic mapping studies, and the results we present here will facilitate the search for the novel genes influencing natural fertility in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.