ArticleGenetics2009
A problem with the correlation coefficient as a measure of gene expression divergence.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Greedy regression-based cross-species gene expression modeling: a translational framework for forensic wound age estimation.International journal of legal medicine · 2026Article
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- Gene function predicts divergence across molecular levels.bioRxiv : the preprint server for biology · 2026Article
- Evolutionary diversification of ancestral genes across vertebrates and insects.Genome biology · 2025Article
- Transitions to asexuality and evolution of gene expression inProceedings. Biological sciences · 2021Article
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- Topologically associating domains and their role in the evolution of genome structure and function inGenome research · 2021Article
- An information-theoretic approach for measuring the distance of organ tissue samples using their transcriptomic signatures.Bioinformatics (Oxford, England) · 2021Article
- A visual analytic approach for the identification of ICU patient subpopulations using ICD diagnostic codes.PeerJ. Computer science · 2021Article
- Corruption of the Pearson correlation coefficient by measurement error and its estimation, bias, and correction under different error models.Scientific reports · 2020Article
- TreeExp2: An Integrated Framework for Phylogenetic Transcriptome Analysis.Genome biology and evolution · 2019Article
- Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks.Genome research · 2019Article
- Rapid turnover of life-cycle-related genes in the brown algae.Genome biology · 2019Article
- Lineage-Specific Expression Divergence in Grasses Is Associated with Male Reproduction, Host-Pathogen Defense, and Domestication.Genome biology and evolution · 2019Article
- Global Dosage Compensation Is Ubiquitous in Lepidoptera, but Counteracted by the Masculinization of the Z Chromosome.Molecular biology and evolution · 2017Article
- The evolution of duplicate gene expression in mammalian organs.Genome research · 2017Article
- A benchmark of gene expression tissue-specificity metrics.Briefings in bioinformatics · 2017Article
- Identifying aggressive prostate cancer foci using a DNA methylation classifier.Genome biology · 2017Article
- Transcriptional Interference Promotes Rapid Expression Divergence of Drosophila Nested Genes.Genome biology and evolution · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The correlation coefficient is commonly used as a measure of the divergence of gene expression profiles between different species. Here we point out a potential problem with this statistic: if measurement error is large relative to the differences in expression, the correlation coefficient will tend to show high divergence for genes that have relatively uniform levels of expression across tissues or time points. We show that genes with a conserved uniform pattern of expression have significantly higher levels of expression divergence, when measured using the correlation coefficient, than other genes, in a data set from mouse, rat, and human. We also show that the Euclidean distance yields low estimates of expression divergence for genes with a conserved uniform pattern of expression.
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