ArticleGenetics2009
Comparative mitochondrial genomics of freshwater mussels (Bivalvia: Unionoida) with doubly uniparental inheritance of mtDNA: gender-specific open reading frames and putative origins of replication.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed.
- Gene Rearrangement in the Mitochondrial Genomes of the Sand Crabs Albunea symmysta (Anomura:Hippoidea) with Insights into Phylogenetic Relationships in the Anomura (Crustacea: Decapoda).Biochemical genetics · 2026Article
- Unstable mitochondrial heteroplasmy inPeerJ · 2026Article
- Gatekeepers of the Germ Line: How Mitochondria Shape Reproductive Evolution in Metazoans.Biology · 2025Review
- Sex-Specific ORFs in Marine Clams (Bivalvia: Veneridae) with Doubly Uniparental Inheritance: Exploring Their Origin and Putative Function.Marine biotechnology (New York, N.Y.) · 2025Article
- Secondary contact erodes Pleistocene diversification in a wide-ranging freshwater mussel (Quadrula).Molecular ecology · 2025Article
- Demystifying the functions of the mitochondrial ORFan proteins in bivalves with doubly uniparental inheritance.Biology letters · 2025Article
- The complete mitochondrial genomes of the freshwater musselMitochondrial DNA. Part B, Resources · 2025Article
- Comparative mitogenomic analysis and phylogeny of Veneridae with doubly uniparental inheritance.Open biology · 2024Article
- ORFans in Mitochondrial Genomes of Marine Polychaete Polydora.Genome biology and evolution · 2023Article
- Article
- A comparative analysis of mitochondrial ORFs provides new insights on expansion of mitochondrial genome size in Arcidae.BMC genomics · 2022Article
- Complete mitochondrial genome of freshwater pearl mussel Lamellidens marginalis (Lamarck, 1819) and its phylogenetic relation within unionidae family.Molecular biology reports · 2022Article
- Confirmation of the first intronic sequence in the bivalvian mitochondrial genome ofBiology letters · 2022Article
- No evidence of DUI in the Mediterranean alien species Brachidontes pharaonis (P. Fisher, 1870) despite mitochondrial heteroplasmy.Scientific reports · 2022Article
- Did doubly uniparental inheritance (DUI) of mtDNA originate as a cytoplasmic male sterility (CMS) system?BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- Molluscan mitochondrial genomes break the rules.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Complete female-transmitted mitochondrial genomes of two freshwater mussels from the Lake Biwa system in Japan:Mitochondrial DNA. Part B, Resources · 2021Article
- Complete F mitochondrial genomes of two freshwater mussels from the Lake Biwa system in Japan:Mitochondrial DNA. Part B, Resources · 2021Article
- Semimytilus algosus: first known hermaphroditic mussel with doubly uniparental inheritance of mitochondrial DNA.Scientific reports · 2020Article
- Unorthodox features in two venerid bivalves with doubly uniparental inheritance of mitochondria.Scientific reports · 2020Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Doubly uniparental inheritance (DUI) of mitochondrial DNA in marine mussels (Mytiloida), freshwater mussels (Unionoida), and marine clams (Veneroida) is the only known exception to the general rule of strict maternal transmission of mtDNA in animals. DUI is characterized by the presence of gender-associated mitochondrial DNA lineages that are inherited through males (male-transmitted or M types) or females (female-transmitted or F types), respectively. This unusual system constitutes an excellent model for studying basic aspects of mitochondrial DNA inheritance and the evolution of mtDNA genomes in general. Here we compare published mitochondrial genomes of unionoid bivalve species with DUI, with an emphasis on characterizing unassigned regions, to identify regions of the F and M mtDNA genomes that could (i) play a role in replication or transcription of the mtDNA molecule and/or (ii) determine whether a genome will be transmitted via the female or the male gamete. Our results reveal the presence of one F-specific and one M-specific open reading frames (ORFs), and we hypothesize that they play a role in the transmission and/or gender-specific adaptive functions of the M and F mtDNA genomes in unionoid bivalves. Three major unassigned regions shared among all F and M unionoid genomes have also been identified, and our results indicate that (i) two of them are potential heavy-strand control regions (O(H)) for regulating replication and/or transcription and that (ii) multiple and potentially bidirectional light-strand origins of replication (O(L)) are present in unionoid F and M mitochondrial genomes. We propose that unassigned regions are the most promising candidate sequences in which to find regulatory and/or gender-specific sequences that could determine whether a mitochondrial genome will be maternally or paternally transmitted.
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