ArticleAntimicrobial agents and chemotherapy2010
Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interethnic differences in pharmacokinetics of antibacterials.Clinical pharmacokinetics · 2015Pooled it
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- Predicting Maternal and Infant Tetrahydrocannabinol Exposure in Lactating Cannabis Users: A Physiologically Based Pharmacokinetic Modeling Approach.Pharmaceutics · 2023Article
- In Vitro and In Vivo Evaluation of Inhalable Ciprofloxacin Sustained Release Formulations.Pharmaceutics · 2023Article
- Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations.Clinical pharmacokinetics · 2022Article
- Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model.Drug metabolism and disposition: the biological fate of chemicals · 2022Article
- Pharmacokinetic herb-drug interactions: Altered systemic exposure and tissue distribution of ciprofloxacin, a substrate of multiple transporters, after combined treatment withFrontiers in pharmacology · 2022Article
- Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate.Antimicrobial agents and chemotherapy · 2019Article
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- Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate.Antimicrobial agents and chemotherapy · 2016Article
- Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam.Antimicrobial agents and chemotherapy · 2016Article
- Simultaneous Semimechanistic Population Analyses of Levofloxacin in Plasma, Lung, and Prostate To Describe the Influence of Efflux Transporters on Drug Distribution following Intravenous and Intratracheal Administration.Antimicrobial agents and chemotherapy · 2016Article
- Development of a Multicompartment Permeability-Limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs.CPT: pharmacometrics & systems pharmacology · 2015Article
- Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin.Antimicrobial agents and chemotherapy · 2015Article
- Permeation of Therapeutic Drugs in Different Formulations across the Airway Epithelium In Vitro.PloS one · 2015Article
- Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin.Antimicrobial agents and chemotherapy · 2014Article
- Covalent modification of a ten-residue cationic antimicrobial peptide with levofloxacin.Frontiers in chemistry · 2014Article
- Aerosol therapy with colistin methanesulfonate: a biopharmaceutical issue illustrated in rats.Antimicrobial agents and chemotherapy · 2010Article
Corrections and comments
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3 authors.
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Abstract
The transport characteristics of six fluoroquinolones (FQs) with various lipophilicities were compared in a Calu-3 cell model. For each FQ, an active polarized transport was observed in the direction of the apical side. However, the apparent permeability of FQs resulted from active transport and passive diffusion that were highly variable between compounds and mainly governed by lipophilicity. Therefore, active transport was predominant for compounds with relatively low lipophilicity but minor for FQs with higher lipophilicity.
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