ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2010
Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Regulation of Cardiac Autonomic Nervous System Control across Frailty Statuses: A Systematic Review.Gerontology · 2015Pooled it
- Can strength training or tai ji quan training reduce frailty in postmenopausal women treated with chemotherapy? A secondary data analysis of the GET FIT trial.Journal of cancer survivorship : research and practice · 2024Trial
- Daily life mobility detects frailty, falls, and functioning in older prostate cancer survivors treated with androgen deprivation therapy.Journal of geriatric oncology · 2025Article
- Daily life mobility detects frailty, falls, and functioning in ADT-treated prostate cancer survivors.Research square · 2024Article
- Chronotropic Response and Heart Rate Variability before and after a 160 m Walking Test in Young, Middle-Aged, Frail, and Non-Frail Older Adults.International journal of environmental research and public health · 2022Article
- Frailty Identification Using Heart Rate Dynamics: A Deep Learning Approach.IEEE journal of biomedical and health informatics · 2022Article
- Frailty assessment using a novel approach based on combined motor and cardiac functions: a pilot study.BMC geriatrics · 2022Article
- Age-Related Differences in the Neural Processing of Idioms: A Positive Perspective.Frontiers in aging neuroscience · 2022Article
- The association between heart rate behavior and gait performance: The moderating effect of frailty.PloS one · 2022Observational
- Physical activity and exercise: Strategies to manage frailty.Redox biology · 2020Review
- What are the illnesses associated with frailty in community-dwelling older adults: the Korean Frailty and Aging Cohort Study.The Korean journal of internal medicine · 2020Article
- Cross-sectional and longitudinal analyses of the association between lung function and exercise capacity in healthy Norwegian men.BMC pulmonary medicine · 2018Observational
- Frailty assessment in the cardiovascular care of older adults.Journal of the American College of Cardiology · 2014Review
- Frailty in older breast cancer survivors: age, prevalence, and associated factors.Oncology nursing forum · 2013Article
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5 authors.
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Abstract
backgroundA decline in exercise capacity (EC) is a characteristic of frailty. We hypothesized that decline is the effect of decrements in several physiological systems. We assessed whether the relationship of three main physiological systems-cardiac, pulmonary, and musculoskeletal-to EC is independent or interactive and whether their effect on EC varies with respect to frailty status.
methodsObservational study of 547 disabled women aged 65 years and older (Women's Health and Aging Study I) including 131 frail who participated in a test of EC. EC (seated step test), cardiac function (chronotropic index), pulmonary function (forced vital capacity, FVC), musculoskeletal function (quadriceps strength, QS), and frailty status were measured and interactive effects were modeled using linear regression and differentiation.
resultsEach physiological system had a direct relationship with EC, which was lower in frail compared with nonfrail. The relationship between FVC and EC was positive and increased with increasing QS in nonfrail subjects. The effect of QS on EC was positive and increased with increasing FVC regardless of frailty. In subjects with low QS, frailty status was associated with lower EC and this effect became stronger with increasing FVC. Discussion Findings suggest but do not show that frailty status modifies the effects of physiological function in several systems on EC. Approaches to understanding emergent properties such as vulnerability to illness and death and clinical efforts to prevent and treat frailty should evaluate and possibly intervene on several physiological systems to be maximally effective.
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