ArticleThe Journal of biological chemistry2009
Evidence for the Existence in Arabidopsis thaliana of the Proteasome Proteolytic Pathway: ACTIVATION IN RESPONSE TO CADMIUM.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 107 citations in OpenAlex.
- Growth and protein response of rice plant with plant growth-promoting rhizobacteria inoculations under salt stress conditions.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Characterization of leucine aminopeptidase (LAP) activity in sweet pepper fruits during ripening and its inhibition by nitration and reducing events.Plant cell reports · 2024Article
- Genome-Wide Identification and Analysis of the Maize Serine Peptidase S8 Family Genes in Response to Drought at Seedling Stage.Plants (Basel, Switzerland) · 2023Article
- Proteome profiles during early stage of somatic embryogenesis of two Eucalyptus species.BMC plant biology · 2022Article
- Redox post-translational modifications and their interplay in plant abiotic stress tolerance.Frontiers in plant science · 2022Review
- Dynamics of Zea mays transcriptome in response to a polyphagous herbivore, Spodoptera litura.Functional & integrative genomics · 2021Article
- Manganese-induced oxidative stress, ultrastructural changes, and proteomics studies in rice plants.Protoplasma · 2021Article
- Hyperaccumulation of cadmium by scallop Chlamys farreri revealed by comparative transcriptome analysis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2020Article
- Early responses of maize seedlings to Cu stress include sharp decreases in gibberellins and jasmonates in the root apex.Protoplasma · 2020Article
- Do plants use root-derived proteases to promote the uptake of soil organic nitrogen?Plant and soil · 2020Article
- Protein Carbonylation As a Biomarker of Heavy Metal, Cd and Pb, Damage inPlants (Basel, Switzerland) · 2019Article
- Multilevel Regulation of Peroxisomal Proteome by Post-Translational Modifications.International journal of molecular sciences · 2019Review
- Molecular evidence for origin, diversification and ancient gene duplication of plant subtilases (SBTs).Scientific reports · 2019Article
- Proteome-Wide Analysis of Cysteine Reactivity during Effector-Triggered Immunity.Plant physiology · 2019Article
- Proteomics: a powerful tool to study plant responses to biotic stress.Plant methods · 2019Review
- Increases in activity of proteasome and papain-like cysteine protease in Arabidopsis autophagy mutants: back-up compensatory effect or cell-death promoting effect?Journal of experimental botany · 2018Article
- Proteomic analysis of heat stress resistance of cucumber leaves when grafted onto Momordica rootstock.Horticulture research · 2018Article
- The Plastid and Mitochondrial Peptidase Network inThe Plant cell · 2017Review
- Over-expression of tobacco UBC1 encoding a ubiquitin-conjugating enzyme increases cadmium tolerance by activating the 20S/26S proteasome and by decreasing Cd accumulation and oxidative stress in tobacco (Nicotiana tabacum).Plant molecular biology · 2017Article
- Opportunistic proteolytic processing of carbonic anhydrase 1 from Chlamydomonas in Arabidopsis reveals a novel route for protein maturation.Journal of experimental botany · 2016Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heavy metals are known to generate reactive oxygen species that lead to the oxidation and fragmentation of proteins, which become toxic when accumulated in the cell. In this study, we investigated the role of the proteasome during cadmium stress in the leaves of Arabidopsis thaliana plants. Using biochemical and proteomics approaches, we present the first evidence of an active proteasome pathway in plants. We identified and characterized the peptidases acting sequentially downstream from the proteasome in animal cells as follows: tripeptidyl-peptidase II, thimet oligopeptidase, and leucine aminopeptidase. We investigated the proteasome proteolytic pathway response in the leaves of 6-week-old A. thaliana plants grown hydroponically for 24, 48, and 144 h in the presence or absence of 50 mum cadmium. The gene expression and proteolytic activity of the proteasome and the different proteases of the pathway were found to be up-regulated in response to cadmium. In an in vitro assay, oxidized bovine serum albumin and lysozyme were more readily degraded in the presence of 20 S proteasome and tripeptidyl-peptidase II than their nonoxidized form, suggesting that oxidized proteins are preferentially degraded by the Arabidopsis 20 S proteasome pathway. These results show that, in response to cadmium, the 20 S proteasome proteolytic pathway is up-regulated at both RNA and activity levels in Arabidopsis leaves and may play a role in degrading oxidized proteins generated by the stress.
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