ReviewJournal of autoimmunity
Autoimmune thyroiditis: a model uniquely suited to probe regulatory T cell function.
Review in Journal of autoimmunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Review
- Potential Association ofMicroorganisms · 2023Review
- Review
- The Essential Role of Circulating Thyroglobulin in Maintaining Dominance of Natural Regulatory T Cell Function to Prevent Autoimmune Thyroiditis.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2015Review
- Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity.Endocrine reviews · 2014Review
- Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.Frontiers in immunology · 2014Review
- Defective expression of regulatory B cells in iodine-induced autoimmune thyroiditis in non-obese diabetic H-2(h4) mice.Journal of endocrinological investigation · 2014Article
- Enhanced autoimmunity associated with induction of tumor immunity in thyroiditis-susceptible mice.Thyroid : official journal of the American Thyroid Association · 2013Article
- Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto's thyroiditis.BMC endocrine disorders · 2013Article
- Hashimoto's Thyroiditis: From Genes to the Disease.Current genomics · 2011Article
- Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2011Article
- Efficacy of HLA-DRB1∗03:01 and H2E transgenic mouse strains to correlate pathogenic thyroglobulin epitopes for autoimmune thyroiditis.Journal of autoimmunity · 2011Article
- To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice.Journal of autoimmunity · 2011Review
- T cell clonal expansions detected in patients with primary biliary cirrhosis express CX3CR1.Journal of autoimmunity · 2011Article
- Autoimmunity and inflammation: murine models and translational studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- A contemporary update on scleroderma.Clinical reviews in allergy & immunology · 2011Article
- Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis.Journal of autoimmunity · 2010Article
- Control of Th2-mediated inflammation by regulatory T cells.The American journal of pathology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Murine experimental autoimmune thyroiditis (EAT) is a model for Hashimoto's thyroiditis that has served as a prototype of T cell-mediated autoimmunity for more than three decades. Key roles for MHC restriction and autoantigen influence on susceptibility to autoimmunity have been demonstrated in EAT. Moreover, it has served a unique role in investigations of self tolerance. In the early 1980s, self tolerance and resistance to EAT induction could be enhanced by increasing circulating levels of the autoantigen, thyroglobulin (Tg), by exogenous addition as well as endogenous release. This observation, directly linking circulating self antigen to self tolerance, led to subsequent investigations of the role of regulatory T cells (Tregs) in self tolerance. These studies revealed that protection against autoimmunity, in both naive and tolerized mice, was mediated by thymically-derived CD4(+)CD25(+)Foxp3(+) Tregs. Moreover, these naturally-existing Tregs required proper costimulation, in context with autoantigen presentation, to maintain and enhance self tolerance. In particular was the selected use of MHC- and heterologous Tg-restricted models from both conventional and transgenic mice. These models helped to elucidate the complex interplay between autoantigen presentation and MHC class II-mediated T cell selection in the development of Treg and autoreactive T cell repertoires determining susceptibility to autoimmunity. Here we describe these investigations in further detail, providing a context for how EAT has helped shape our understanding of self tolerance and autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.