ArticleNeurobiology of disease2010
AMPA and metabotropic excitoxicity explain subplate neuron vulnerability.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Neonatal Hypoxia-Ischemia Causes Functional Circuit Changes in Subplate Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- The Superior Function of the Subplate in Early Neocortical Development.Frontiers in neuroanatomy · 2018Review
- Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.Frontiers in cellular neuroscience · 2017Review
- Unbiased Quantification of Subplate Neuron Loss following Neonatal Hypoxia-Ischemia in a Rat Model.Developmental neuroscience · 2017Article
- Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System.PloS one · 2016Article
- Subplate in a rat model of preterm hypoxia-ischemia.Annals of clinical and translational neurology · 2014Article
- What are the Best Animal Models for Testing Early Intervention in Cerebral Palsy?Frontiers in neurology · 2014Review
- Calcium-permeable AMPA receptors in neonatal hypoxic-ischemic encephalopathy (Review).Biomedical reports · 2013Article
- Regional brain injury on conventional and diffusion weighted MRI is associated with outcome after pediatric cardiac arrest.Neurocritical care · 2013Article
- Early diffusion-weighted magnetic resonance imaging in children after cardiac arrest may provide valuable prognostic information on clinical outcome.Intensive care medicine · 2013Article
- Expression of EAAT2 in neurons and protoplasmic astrocytes during human cortical development.The Journal of comparative neurology · 2012Article
- The Long and the Short of it: Gene and Environment Interactions During Early Cortical Development and Consequences for Long-Term Neurological Disease.Frontiers in psychiatry · 2012Article
- Imaging selective vulnerability in the developing nervous system.Journal of anatomy · 2010Review
- Neurobiology of injury to the developing brain.Nature reviews. Neurology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cerebral hypoxia-ischemia results in unique patterns of injury during development owing to selective vulnerability of specific cell populations including subplate neurons. To evaluate the contribution of glutamate excitotoxicity, we studied enriched cultures of subplate neurons in comparison with cortical neurons, deriving expression profiles for glutamate receptor subunits by microarray and immunoblot. The excitotoxic potency of specific glutamate receptors was tested with selective agonists and antagonists. After 1 week in culture, subplate neurons are more sensitive to oxygen-glucose deprivation than cortical neurons, confirming in vivo observations. Subplate and cortical neurons are equally sensitive to glutamate and insensitive to NMDA. Subplate neurons are more sensitive than cortical neurons to AMPA and express twofold less GluR2. Subplate neurons express significantly more mGluR3, a receptor proposed to be protective. Despite this increased expression, group II mGluR agonists increase subplate neuron death and antagonists lessen glutamate excitotoxicity, suggesting a novel mechanism for subplate vulnerability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.