ArticleHepatology (Baltimore, Md.)2009
Mechanistic insights into immunomodulation by hepatic stellate cells in mice: a critical role of interferon-gamma signaling.
Article in Hepatology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 71 citations in OpenAlex.
- Clinicopathological features of graft versus host disease-associated myositis.Annals of clinical and translational neurology · 2024Review
- Unlocking the post-transplant microenvironment for successful islet function and survival.Frontiers in endocrinology · 2023Review
- Targeting HIF-1α abrogates PD-L1-mediated immune evasion in tumor microenvironment but promotes tolerance in normal tissues.The Journal of clinical investigation · 2022Article
- Mechanisms of immune checkpoint inhibitor-mediated liver injury.Acta pharmaceutica Sinica. B · 2021Review
- PMA induces the differentiation of monocytes into immunosuppressive MDSCs.Clinical and experimental immunology · 2021Article
- Suppression of liver transplant rejection by anti-donor MHC antibodies via depletion of donor immunogenic dendritic cells.International immunology · 2021Article
- Mesenchymal stromal cells for corneal transplantation: Literature review and suggestions for successful clinical trials.The ocular surface · 2021Review
- Liver, Tumor and Viral Hepatitis: Key Players in the Complex Balance Between Tolerance and Immune Activation.Frontiers in immunology · 2020Review
- The role of the liver in the migration of parasites of global significance.Parasites & vectors · 2019Review
- Hepatic Stellate Cells Enhance Liver Cancer Progression by Inducing Myeloid-Derived Suppressor Cells through Interleukin-6 Signaling.International journal of molecular sciences · 2019Article
- Engineering human stellate cells for beta cell replacement therapy promotesMaterials today. Bio · 2019Article
- Why some organ allografts are tolerated better than others: new insights for an old question.Current opinion in organ transplantation · 2019Review
- The Role Of Hepatic Stellate Cells In Promoting Liver Metastasis Of Colorectal Carcinoma.OncoTargets and therapy · 2019Article
- Novel Effector Phenotype of Tim-3Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- C-C Chemokine Receptor Type 2-Dependent Migration of Myeloid-Derived Suppressor Cells in Protection of Islet Transplants.Transplantation · 2017Article
- Stellate Cell Activation and Imbalanced Expression of TGF-BioMed research international · 2017Article
- Presentation of hepatocellular antigens.Cellular & molecular immunology · 2016Review
- Immunological aspects of liver cell transplantation.World journal of transplantation · 2016Review
- Hepatic Stellate Cells Directly Inhibit B Cells via Programmed Death-Ligand 1.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications.Liver international : official journal of the International Association for the Study of the Liver · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledThe liver is considered to be an immune-privileged organ that favors the induction of tolerance. The underlying mechanisms are not completely understood. Interestingly, liver transplants are spontaneously accepted in several animal models, but hepatocyte transplants are acutely rejected, suggesting that liver nonparenchymal cells may effectively protect the parenchymal cells from immune attack. We have shown the profound T cell inhibitory activity of hepatic stellate cells (HSCs). Thus, cotransplantation with HSCs effectively protects islet allografts from rejection in mice. In this study, using T cell receptor transgenic and gene knockout approaches, we provided definitive evidence that HSCs protected cotransplanted islet allografts by exerting comprehensive inhibitory effects on T cells, including apoptotic death in graft-infiltrating antigen-specific effector T cells and marked expansion of CD4(+) Forkhead box protein (Foxp)3(+) T regulatory (Treg) cells. All these effects required an intact interferon-gamma (IFN-gamma) signaling in HSCs, demonstrated by using HSCs isolated from IFN-gamma receptor 1 knockout mice. B7-H1 expression on HSCs, a product molecule of IFN-gamma signaling, was responsible for induction of T cells apoptosis, but had no effect on expansion of Treg cells, suggesting that undetermined effector molecules produced by IFN-gamma signaling is involved in this process.
conclusionUpon inflammatory stimulation, specific organ stromal cells (such as HSCs in the liver) demonstrate potent immune regulatory activity. Understanding of the mechanisms involved may lead to development of novel strategies for clinical applications in transplantation and autoimmune diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.