ArticleDiabetologia2009
Heritability of insulin sensitivity and lipid profile depend on BMI: evidence for gene-obesity interaction.
Article in Diabetologia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Pooled it
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Nature genetics · 2012Pooled it
- Quantile-Dependent Heritability of Glucose, Insulin, Proinsulin, Insulin Resistance, and Glycated Hemoglobin.Lifestyle genomics · 2022Article
- Clinical Characteristics of Lipid Metabolism in Untreated Patients with Anti-MDA5 Antibody-Positive.International journal of general medicine · 2021Article
- Heritability of Vascular Structure and Function: A Parent-Child Study.Journal of the American Heart Association · 2017Article
- Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes.American journal of human genetics · 2016Article
- Metabolic regulation and energy homeostasis through the primary Cilium.Cell metabolism · 2015Review
- Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.Molecular psychiatry · 2014Article
- IGF2BP2 and obesity interaction analysis for type 2 diabetes mellitus in Chinese Han population.European journal of medical research · 2014Article
- Genetic risk score and adiposity interact to influence triglyceride levels in a cohort of Filipino women.Nutrition & diabetes · 2014Article
- Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs.PloS one · 2013Article
- Association of adiposity trajectories with insulin sensitivity and glycemic deterioration: a longitudinal study of rural Chinese twin adults.Diabetes care · 2012Article
- Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits.Diabetologia · 2012Article
- A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.PLoS genetics · 2011Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
aims/hypothesisEvidence from candidate gene studies suggests that obesity may modify genetic susceptibility to type 2 diabetes and dyslipidaemia. On an aggregate level, gene-obesity interactions are expected to result in different heritability estimates at different obesity levels. However, this hypothesis has never been tested.
methodThe present study included 2,180 British female twins. BMI was used as an index of general obesity. Outcome measures were insulin sensitivity (indexed by quantitative insulin-sensitivity check index [QUICKI]) and fasting plasma lipid profile. Structural equation modelling was used to test whether BMI interacted with latent genetic and environmental effects to impact on the outcome measures.
resultsGenetic influences on triacylglycerol increased with BMI (p < 0.001) whereas the unique environmental influence on QUICKI decreased with BMI (p < 0.001), resulting in a higher heritability estimate for both measures at higher BMI levels. This was further illustrated by stratified analysis in twin pairs concordant for normal weight and twin pairs concordant for overweight. Heritability was 19 percentage points higher for triacylglycerol (p < 0.001) and 31 percentage points higher for QUICKI (p < 0.01) among twins concordant for overweight than among twins concordant for normal weight. BMI had no moderator effect on the latent genetic and environmental factors for total cholesterol and HDL-cholesterol. CONCLUSIONS/
interpretationOur results suggest that the expression of genes influencing triacylglycerol and insulin sensitivity can vary as a function of obesity status. The substantial increases in the genetic contribution to the total variance in insulin sensitivity and triacylglycerols at higher BMIs may prove extremely valuable in the search for candidate genes.
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Registered trials
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