ArticleNature cell biology2009
Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome.
Article in Nature cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed, 209 citations in OpenAlex.
- Regulated Cell Death in Fungi, the Role of Metacaspases and Assay Techniques.Methods and protocols · 2026Review
- A sterility-associated long noncoding RNA involved in honey bee caste determination and adult queen and worker fertility.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Plant caspase-like proteins: from function identification to application in winter rapeseed genetic breeding.Frontiers in plant science · 2026Review
- Review
- Viral proteins suppress rice defenses by boosting OsTSN1 RNA decay via phase separation and multimerization.Nature communications · 2025Article
- Structural determinants for pH-dependent activation of a plant metacaspase.Nature communications · 2025Article
- The Valsa mali Effector VmSR1 Accelerates the Degradation of Tudor-SN2 to Suppress RNA Silencing and Plant Immunity.Molecular plant pathology · 2025Article
- The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells.Cell death discovery · 2025Article
- Seed longevity is controlled by metacaspases.Nature communications · 2024Article
- Thermoprotection by a cell membrane-localized metacaspase in a green alga.The Plant cell · 2024Article
- Apoptotic Factors Are Evolutionarily Conserved Since Mitochondrial Domestication.Genome biology and evolution · 2023Article
- Characterising the Gene Expression, Enzymatic Activity and Subcellular Localisation ofBiology · 2023Article
- The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.FASEB bioAdvances · 2023Article
- Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.Frontiers in oncology · 2022Article
- Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis.The EMBO journal · 2021Article
- The tale of caspase homologues and their evolutionary outlook: deciphering programmed cell death in cyanobacteria.Journal of experimental botany · 2020Article
- Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.Nucleic acids research · 2020Article
- Structural basis for CaNature communications · 2020Article
- Oncoprotein SND1 hijacks nascent MHC-I heavy chain to ER-associated degradation, leading to impaired CD8Science advances · 2020Article
- Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.Molecular cell · 2020Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Programmed cell death (PCD) is executed by proteases, which cleave diverse proteins thus modulating their biochemical and cellular functions. Proteases of the caspase family and hundreds of caspase substrates constitute a major part of the PCD degradome in animals. Plants lack close homologues of caspases, but instead possess an ancestral family of cysteine proteases, metacaspases. Although metacaspases are essential for PCD, their natural substrates remain unknown. Here we show that metacaspase mcII-Pa cleaves a phylogenetically conserved protein, TSN (Tudor staphylococcal nuclease), during both developmental and stress-induced PCD. TSN knockdown leads to activation of ectopic cell death during reproduction, impairing plant fertility. Surprisingly, human TSN (also known as p100 or SND1), a multifunctional regulator of gene expression, is cleaved by caspase-3 during apoptosis. This cleavage impairs the ability of TSN to activate mRNA splicing, inhibits its ribonuclease activity and is important for the execution of apoptosis. Our results establish TSN as the first biological substrate of metacaspase and demonstrate that despite the divergence of plants and animals from a common ancestor about one billion years ago and their use of distinct PCD pathways, both have retained a common mechanism to compromise cell viability through the cleavage of the same substrate, TSN.
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