ReviewHealth physics2009
Radiation carcinogenesis in context: how do irradiated tissues become tumors?
Review in Health physics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Ionizing radiation triggers the release of mitochondrial DNA into the cytosol as a signal of mitochondrial damage.Scientific reports · 2025Article
- Factors associated with radiographic progression and neurologic decline in patients with isolated traumatic subarachnoid hemorrhage.Chinese neurosurgical journal · 2024Article
- Predictive DNA damage signaling for low‑dose ionizing radiation.International journal of molecular medicine · 2024Article
- Short- and long-term effects of radiation exposure at low dose and low dose rate in normal human VH10 fibroblasts.Frontiers in public health · 2023Article
- Dysregulations of long non-coding RNAs - The emerging "lnc" in environmental carcinogenesis.Seminars in cancer biology · 2021Review
- Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast.Archives of toxicology · 2020Review
- The Implications of Genetic Testing on Radiation Therapy Decisions: A Guide for Radiation Oncologists.International journal of radiation oncology, biology, physics · 2019Review
- Radiation-induced malignancies after intensity-modulated versus conventional mediastinal radiotherapy in a small animal model.Scientific reports · 2019Article
- Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy.Medical physics · 2019Article
- Presence of Stromal Cells Enhances Epithelial-to-Mesenchymal Transition (EMT) Induction in Lung Bronchial Epithelium after Protracted Exposure to Oxidative Stress of Gamma Radiation.Oxidative medicine and cellular longevity · 2019Article
- Effect of internal contamination with tritiated water on the neoplastic colonies in the lungs, innate anti-tumour reactions, cytokine profile, and haematopoietic system in radioresistant and radiosensitive mice.Radiation and environmental biophysics · 2018Article
- Researches of Epigenetic Epidemiology for Infections and Radiation as Carcinogen.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2018Review
- [Second neoplasms after percutaneous radiotherapy].Der Urologe. Ausg. A · 2017Review
- Lesion complexity drives age related cancer susceptibility in human mammary epithelial cells.Aging · 2017Article
- Article
- Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons.Frontiers in oncology · 2015Article
- Article
- Radiation-induced sarcomas of the head and neck.World journal of clinical oncology · 2014Review
- Space radiation risks for astronauts on multiple International Space Station missions.PloS one · 2014Article
- Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice.Journal of radiation research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It is clear from experimental studies that genotype is an important determinant of cancer susceptibility in general, and for radiation carcinogenesis specifically. It has become increasingly clear that genotype influences not only the ability to cope with DNA damage but also influences the cooperation of other tissues, like the vasculature and immune system, necessary for the establishment of cancer. Our experimental data and that of others suggest that the carcinogenic action of ionizing radiation (IR) can also be considered a two-compartment problem: while IR can alter genomic sequence as a result of DNA damage, it can also induce signals that alter multicellular interactions and phenotypes that underpin carcinogenesis. Rather than being accessory or secondary to genetic damage, we propose that such non-targeted radiation effects create the critical context that promotes cancer development. This review focuses on experimental studies that clearly define molecular mechanisms by which cell interactions contribute to cancer in different organs, and addresses how non-targeted radiation effects may similarly act though the microenvironment. The definition of non-targeted radiation effects and their dose dependence could modify the current paradigms for radiation risk assessment since radiation non-targeted effects, unlike DNA damage, are amenable to intervention. The implications of this perspective in terms of reducing cancer risk after exposure are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.