ArticleProceedings of the National Academy of Sciences of the United States of America2009
VIP1 response elements mediate mitogen-activated protein kinase 3-induced stress gene expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 142 citations in OpenAlex.
- Ancient Whole-Genome Duplication and Lineage-Specific Retention Shape the Diversification of bZIP Transcription Factors in Pooideae.Plants (Basel, Switzerland) · 2026Article
- Transgenic validation of a promoter strongly inducible by Agrobacterium tumefaciens.Scientific reports · 2025Article
- Mechanically induced localisation of SECONDARY WALL INTERACTING bZIP is associated with thigmomorphogenic and secondary cell wall gene expression.Quantitative plant biology · 2024Article
- MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis.Plant communications · 2023Article
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- Deciphering the mechanisms, hormonal signaling, and potential applications of endophytic microbes to mediate stress tolerance in medicinal plants.Frontiers in plant science · 2023Review
- Mitogen-Activated Protein Kinases Associated Sites of Tobacco Repression of Shoot Growth Regulates Its Localization in Plant Cells.International journal of molecular sciences · 2022Article
- Agrobacterium-mediated gene transfer: recent advancements and layered immunity in plants.Planta · 2022Review
- Transcriptome Sequence Analysis of the Defense Responses of Resistant and Susceptible Cucumber Strains toFrontiers in plant science · 2022Article
- Editorial: Protein phosphorylation and dephosphorylation in plant-microbe interactions.Frontiers in plant science · 2022Article
- Fungal F8-Culture Filtrate Induces Tomato Resistance against Tomato Yellow Leaf Curl Thailand Virus.Viruses · 2021Article
- Article
- MKK4/5-MPK3/6 Cascade RegulatesFrontiers in plant science · 2021Article
- Article
- Target of Rapamycin Signaling in Plant Stress Responses.Plant physiology · 2020Review
- Comparative Root Transcriptomics Provide Insights into Drought Adaptation Strategies in Chickpea (International journal of molecular sciences · 2020Article
- Article
- VIP1, a bZIP protein, interacts with the catalytic subunit of protein phosphatase 2A in Arabidopsis thaliana.Plant signaling & behavior · 2020Article
- Protein phosphatase 2A regulates the nuclear accumulation of the Arabidopsis bZIP protein VIP1 under hypo-osmotic stress.Journal of experimental botany · 2019Article
- OsbZIP81, A Homologue of Arabidopsis VIP1, May Positively Regulate JA Levels by Directly Targetting the Genes in JA Signaling and Metabolism Pathway in Rice.International journal of molecular sciences · 2019Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant pathogen Agrobacterium tumefaciens transforms plant cells by delivering its T-DNA into the plant cell nucleus where it integrates into the plant genome and causes tumor formation. A key role of VirE2-interacting protein 1 (VIP1) in the nuclear import of T-DNA during Agrobacterium-mediated plant transformation has been unravelled and VIP1 was shown to undergo nuclear localization upon phosphorylation by the mitogen-activated protein kinase MPK3. Here, we provide evidence that VIP1 encodes a functional bZIP transcription factor that stimulates stress-dependent gene expression by binding to VIP1 response elements (VREs), a DNA hexamer motif. VREs are overrepresented in promoters responding to activation of the MPK3 pathway such as Trxh8 and MYB44. Accordingly, plants overexpressing VIP1 accumulate high levels of Trxh8 and MYB44 transcripts, whereas stress-induced expression of these genes is impaired in mpk3 mutants. Trxh8 and MYB44 promoters are activated by VIP1 in a VRE-dependent manner. VIP1 strongly enhances expression from a synthetic promoter harboring multiple VRE copies and directly interacts with VREs in vitro and in vivo. Chromatin immunoprecipitation assays of the MYB44 promoter confirm that VIP1 binding to VREs is enhanced under conditions of MPK3 pathway stimulation. These results provide molecular insight into the cellular mechanism of target gene regulation by the MPK3 pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.