ArticleClinical journal of the American Society of Nephrology : CJASN2009
Topical mupirocin/sodium hypochlorite reduces peritonitis and exit-site infection rates in children.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 42 citations in OpenAlex.
- A randomized controlled trial comparing mupirocin and polysporin triple ointments in peritoneal dialysis patients: the MP3 Study.Clinical journal of the American Society of Nephrology : CJASN · 2012Trial
- Exit-Site Care in Pediatric Peritoneal Dialysis Patients: From Personal Preference to Clinical Evidence.Kidney international reports · 2025Article
- Universal Exit-Site Antibiotic Prophylaxis Reduces Exit-Site Infections in Pediatric Peritoneal Dialysis.Kidney international reports · 2025Article
- Peritoneal dialysis-related infections recommendations: 2016 update. What is new?International urology and nephrology · 2017Review
- Comparing the Effect of Dressing Versus No-dressing on Exit Site Infection and Peritonitis in Chronic Ambulatory Peritoneal Dialysis Patients.Advanced biomedical research · 2017Article
- ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2016Review
- Readmission within 30 days of hospital discharge among children receiving chronic dialysis.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Outcomes of peritonitis in children on peritoneal dialysis: a 25-year experience at Severance Hospital.Yonsei medical journal · 2013Article
- Consensus guidelines for the prevention and treatment of catheter-related infections and peritonitis in pediatric patients receiving peritoneal dialysis: 2012 update.Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis · 2012Review
- Peritoneal dialysis in children with end-stage renal disease.Nature reviews. Nephrology · 2011Review
- Epidemiology and outcomes of peritonitis in children on peritoneal dialysis in Australasia.Pediatric nephrology (Berlin, Germany) · 2010Article
- Dialysis: The importance of peritoneal catheter exit-site care.Nature reviews. Nephrology · 2010Article
- Ofloxacin solution for persistent exit-site and tunnel infection in peritoneal dialysis.Peritoneal dialysis international : journal of the International Society for Peritoneal DialysisArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPeritoneal dialysis (PD) is a common maintenance renal replacement modality for children with ESRD frequently compromised by infectious peritonitis and catheter exit site and tunnel infections (ESI/TI). The effect of topical mupirocin (Mup) and sodium hypochlorite (NaOCl) solution was evaluated as part of routine daily exit site care on peritonitis and ESI/TI rates, causative microorganisms, and catheter survival rates. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Retrospective chart review of children on home continuous cycling PD between April 1, 2001 and June 30, 2007 was performed. Infection rates were examined based on exit site protocol used in two different periods: Mup alone, April 1, 2001 to November 17, 2004; and Mup and NaOCl (Mup+NaOCl), November 18, 2004 to June 30, 2007.
resultsEighty-three patients (mean PD initiation age: 12.1 +/- 5.8 yr) received home PD over 2009 patient months. Annualized rates (ARs) for peritonitis decreased from 1.2 in the Mup period to 0.26 in the Mup+NaOCl period (P < 0.0001). ARs for ESI/TI decreased from 1.36 in the Mup period to 0.33 in the Mup+NaOCl period (P < 0.0001). No infections with Mup-resistant organisms were observed when either Mup or Mup+NaOCl was used for prophylaxis. Gram-negative-organism associated peritonitis decreased from an AR of 0.31 in the Mup period to 0.07 in the Mup+NaOCl period (P < 0.001). Infection-related catheter removal rates decreased from 1 in 38.9 catheter-months in the Mup period to 1 in 94.2 in the Mup+NaOCl period (P = 0.01). Catheter survival rates were longer in the Mup+NaOCl period (Kaplan-Meier, P < 0.009).
conclusionsThe combination Mup+NaOCl in daily exit site care was very effective to reduce PD catheter-associated infections and prolong catheter survival in pediatric patients.
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