ArticleEukaryotic cell2009
Regulatory diversity of TUP1 in Cryptococcus neoformans.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Resistance gene mutations and phylogenetic relationships inFrontiers in cellular and infection microbiology · 2026Article
- The "Little Iron Waltz": The Ternary Response ofJournal of fungi (Basel, Switzerland) · 2020Review
- Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype.PLoS pathogens · 2019Article
- Fungal Quorum-Sensing Molecules and Inhibitors with Potential Antifungal Activity: A Review.Molecules (Basel, Switzerland) · 2019Review
- Diverse roles of Tup1p and Cyc8p transcription regulators in the development of distinct types of yeast populations.Current genetics · 2019Review
- Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi.Molecular microbiology · 2018Review
- Physiological Differences in Cryptococcus neoformans StrainsAntimicrobial agents and chemotherapy · 2017Review
- Comparative Ecology of CapsularFrontiers in microbiology · 2017Article
- The Coprinopsis cinerea Tup1 homologue Cag1 is required for gill formation during fruiting body morphogenesis.Biology open · 2016Article
- Intracellular Action of a Secreted Peptide Required for Fungal Virulence.Cell host & microbe · 2016Article
- MoTup1 is required for growth, conidiogenesis and pathogenicity of Magnaporthe oryzae.Molecular plant pathology · 2015Article
- Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation.Genome research · 2015Article
- Functional profiling of human fungal pathogen genomes.Cold Spring Harbor perspectives in medicine · 2014Review
- A Ferroxidase, Cfo1, Regulates Diverse Environmental Stress Responses of Cryptococcus neoformans through the HOG Pathway.Mycobiology · 2014Article
- Article
- Congenic strains for genetic analysis of virulence traits in Cryptococcus gattii.Infection and immunity · 2013Article
- Article
- The Cryptococcus neoformans capsule: a sword and a shield.Clinical microbiology reviews · 2012Review
- Quorum sensing in fungi--a review.Medical mycology · 2012Review
- Adaptation of Cryptococcus neoformans to mammalian hosts: integrated regulation of metabolism and virulence.Eukaryotic cell · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cryptococcus neoformans serotype A strains, the major cause of cryptococcosis, are distributed worldwide, while serotype D strains are more concentrated in Central Europe. We have previously shown that deletion of the global regulator TUP1 in serotype D isolates results in a novel peptide-mediated, density-dependent growth phenotype that mimics quorum sensing and is not known to exist in other fungi. Unlike for tup1Delta strains of serotype D, the density-dependent growth phenotype was found to be absent in tup1Delta strains of serotype A which had been derived from several different genetic clusters. The serotype A H99 tup1Delta strain showed less retardation in the growth rate than tup1Delta strains of serotype D, but the mating efficiency was found to be similar in both serotypes. Deletion of TUP1 in the H99 strain resulted in significantly enhanced capsule production and defective melanin formation and also revealed a unique regulatory role of the TUP1 gene in maintaining iron/copper homeostasis. Differential expression of various genes involved in capsule formation and iron/copper homeostasis was observed between the wild-type and tup1Delta H99 strains. Furthermore, the H99 tup1Delta strain displayed pleiotropic effects which included sensitivity to sodium dodecyl sulfate, susceptibility to fluconazole, and attenuated virulence. These results demonstrate that the global regulator TUP1 has pathobiological significance and plays both conserved and distinct roles in serotype A and D strains of C. neoformans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.