Evidence map›Paper›PMID 19820087›Full record

ArticleJournal of bacteriology2009

A typhus group-specific protease defies reductive evolution in rickettsiae.

Nicole C Ammerman, Joseph J Gillespie, Andrew F Neuwald, Bruno W Sobral, Abdu F Azad

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Metagenome diversity illuminates origins of pathogen effectors.bioRxiv : the preprint server for biology · 2023
    Article
  3. Review
  4. Article
  5. Secretome of obligate intracellular Rickettsia.FEMS microbiology reviews · 2015
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicole C AmmermanDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Joseph J Gillespie
Andrew F Neuwald
Bruno W Sobral
Abdu F Azad
University of Maryland, Baltimore · USVirginia Tech · US

Funding

MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSIONR01AI017828 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAHMAN, MOHAMMED SAYEEDUR · 1985 to 2022
$10.2M
Generation of Genetically Attenuated RickettsiaeR01AI059118 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI AZAD, ABDU F · 2005 to 2009
$2.1M
Predicting common protein mechanisms by the light of evolutionR01GM078541 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI NEUWALD, ANDREW F · 2006 to 2009
$1.0M
NIAID NIH HHS R01 AI017828NIAID NIH HHS R01AI017828NIAID NIH HHS R01 AI059118NIAID NIH HHS R01AI59118NIGMS NIH HHS GM078541NIGMS NIH HHS R01 GM078541PHS HHS HHSN266200400035C
6 · The paper itself

Abstract

Phylogenomics reveals extreme gene loss in typhus group (TG) rickettsiae relative to the levels for other rickettsial lineages. We report here a curious protease-encoding gene (ppcE) that is conserved only in TG rickettsiae. As a possible determinant of host pathogenicity, ppcE warrants consideration in the development of therapeutics against epidemic and murine typhus.

Indexed as

Evolution, MolecularAmino Acid SequenceBacterial ProteinsConserved SequenceModels, MolecularMolecular Sequence DataPhylogenyProtein Structure, TertiaryRickettsieaeSequence AlignmentSerine EndopeptidasesBacterial Proteinsgroup-specific proteaseSerine Endopeptidases

Identifiers

PMID19820087
PMCPMC2786609
OpenAlexW2016133213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.