Trial reportChest2010
The effect of active and passive household cigarette smoke exposure on pregnant women with asthma.
Trial report in Chest, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Risk factors for asthma exacerbations during pregnancy: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder.Autism : the international journal of research and practice · 2021Article
- Lifestyle and Outcomes of Assisted Reproductive Techniques: A Narrative Review.Global journal of health science · 2015Review
- The health burden of pollution: the impact of prenatal exposure to air pollutants.International journal of chronic obstructive pulmonary disease · 2015Review
- Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine.Environmental health perspectives · 2015Review
- Passive smoking is associated with poor asthma control during pregnancy: a prospective study of 500 pregnancies.PloS one · 2014Observational
- Asthma in pregnancy: a review.Obstetric medicine · 2013Review
- Asthma and pregnancy.Clinical reviews in allergy & immunology · 2012Review
- Sources and frequency of secondhand smoke exposure during pregnancy.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 15 institutions in 1 country.
Funding
Abstract
backgroundThe article was designed to estimate the effect of active and passive household cigarette smoke exposure on asthma severity and obstetric and neonatal outcomes in pregnant women with asthma.
methodsWe used a secondary observational analysis of pregnant women with mild and moderate-severe asthma enrolled in a prospective observational cohort study of asthma in pregnancy and a randomized clinical trial (RCT) comparing inhaled beclomethasone and oral theophylline. A baseline questionnaire detailing smoking history and passive household smoke exposure was given to each patient. Smoking status was confirmed in the RCT using cotinine levels. Data on asthma severity and obstetric and neonatal outcomes were collected and analyzed with respect to self-reported tobacco smoke exposure. Kruskal-Wallis and Pearson chi(2) statistics were used to test for significance.
resultsA total of 2,210 women were enrolled: 1,812 in the observational study and 398 in the RCT. Four hundred and eight (18%) women reported current active smoking. Of the nonsmokers, 790 (36%) women reported passive household smoke exposure. Active smoking was associated with more total symptomatic days (P < .001) and nights of sleep disturbance (P < .001). Among the newborns of active smokers, there was a greater risk of small for gestational age < 10th percentile (P < .001), and a lower mean birth weight (P < .001). There were no differences in symptom exacerbation or outcome between nonsmokers with and without passive household cigarette smoke exposure.
conclusionsAmong pregnant women with asthma, active but not passive smoking is associated with increased asthma symptoms and fetal growth abnormalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.